Show simple item record

dc.contributor.authorGong, Yi
dc.contributor.authorLiu, Qing Lin
dc.contributor.authorZhu, Ai Mei
dc.contributor.authorZhang, Qiu Gen
dc.contributor.author张秋根
dc.date.accessioned2013-01-25T09:10:00Z
dc.date.available2013-01-25T09:10:00Z
dc.date.issued2012-09-01
dc.identifier.citationCARBOHYDRATE POLYMERS,2012,90(1):690-695zh_CN
dc.identifier.issn0144-8617
dc.identifier.urihttp://dx.doi.org/10.1016/j.carbpol.2012.05.098
dc.identifier.uriWOS:000308267000092
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/14742
dc.description.abstractThis work presents a new approach for the synthesis of multiresponsive composite microspheres of PNIPAM/chitosan. The resulting microspheres in a sandwich structure with PNIPAM nanoparticles embedded in the crosslinked chitosan matrix were characterized. Compared to other preparation methods, this proposed technique not only is a facile route but also endows the microspheres a desirable structure. The products undergo a temperature induced volume phase transition and exhibit an appreciable pH response. They are further tested as drug carriers to investigate potential application. The encapsulation efficiency in acidic environment (pH = 4.0) is 73.5% and much higher than that in neutral (20.3%, pH = 6.9) and alkaline (15.1%, pH = 9.2) environments. The release of the drug from the microspheres can be controlled by pH and temperature. (C) 2012 Elsevier Ltd. All rights reserved.zh_CN
dc.description.sponsorshipNational Nature Science Foundation of China [20976145, 21076170, 21107089]; Nature Science Foundation of Fujian Province of China [2009J01040, 2011J01055]; research fund for the Doctoral Program of Higher Education [20090121110031, 20110121120041]zh_CN
dc.language.isoenzh_CN
dc.publisherELSEVIER SCI LTDzh_CN
dc.subjectOne-pot synthesiszh_CN
dc.subjectMultisensitive microsphereszh_CN
dc.subjectChitosanzh_CN
dc.subjectPoly(N-isopropylacrylamide)zh_CN
dc.subjectDrug deliveryzh_CN
dc.titleOne-pot synthesis of poly(N-isopropylacrylamide)/chitosan composite microspheres via microemulsionzh_CN
dc.typeArticlezh_CN


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record