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dc.contributor.authorDai Xijie
dc.contributor.authorHuang Peiqiang
dc.contributor.author黄培强
dc.date.accessioned2013-01-24T01:20:06Z
dc.date.available2013-01-24T01:20:06Z
dc.date.issued2012-09
dc.identifier.citationCHINESE JOURNAL OF CHEMISTRY,2012,30(9):1953-1956zh_CN
dc.identifier.issn1001-604X
dc.identifier.urihttp://dx.doi.org/10.1002/cjoc.201200660
dc.identifier.uriWOS:000309400700006
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/14672
dc.description.abstractA novel strategy was developed for a rapid access to the naturally occurring racemic neoclausenamide and its analogs, which featured a highly erythro-selective vinylogous Mukaiyama type reaction (dr=12:1) and a highly diastereoselective tandem conjugate addition-Davis oxidation of N-Boc-pyrrol-2(5H)-one 5 (dr=10:1). Remarkably, the skeleton of neoclausenamide, namely 8a, an analog of neoclausenamide, was built in just two steps with all the four stereogenic centers (relative stereochemistry) established correctly and in excellent diastereoselectivities.zh_CN
dc.description.sponsorshipNational Basic Research Program (973 Program) of China [2010CB833200]; NSF of China [20832005, 20902075]zh_CN
dc.language.isoenzh_CN
dc.publisherWILEY-V C H VERLAG GMBHzh_CN
dc.subject( plus /-)-neoclausenamidezh_CN
dc.subjectvinylogous Mukaiyama reactionzh_CN
dc.subjecttandem reactionzh_CN
dc.subjectstereoselective synthesiszh_CN
dc.subjectpyrrol-2(5H)-onezh_CN
dc.titleA Short and Flexible Synthetic Approach to the Naturally Occurring Racemic Neoclausenamide and Its Analogszh_CN
dc.typeArticlezh_CN


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