A Short and Flexible Synthetic Approach to the Naturally Occurring Racemic Neoclausenamide and Its Analogs
- 化学化工－已发表论文 
A novel strategy was developed for a rapid access to the naturally occurring racemic neoclausenamide and its analogs, which featured a highly erythro-selective vinylogous Mukaiyama type reaction (dr=12:1) and a highly diastereoselective tandem conjugate addition-Davis oxidation of N-Boc-pyrrol-2(5H)-one 5 (dr=10:1). Remarkably, the skeleton of neoclausenamide, namely 8a, an analog of neoclausenamide, was built in just two steps with all the four stereogenic centers (relative stereochemistry) established correctly and in excellent diastereoselectivities.
CitationCHINESE JOURNAL OF CHEMISTRY，2012,30（9）：1953-1956