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dc.contributor.authorChen Yong-Jing
dc.contributor.authorWang Xiao-Hua
dc.contributor.authorHuang Zhen-Zhen
dc.contributor.authorLin Lin
dc.contributor.authorGao Yao
dc.contributor.authorZhu Er-Yi
dc.contributor.author朱尔一
dc.contributor.authorXing Jin-Chun
dc.contributor.authorZheng Jia-Xin
dc.contributor.authorHang Wei
dc.date.accessioned2013-01-22T01:41:11Z
dc.date.available2013-01-22T01:41:11Z
dc.date.issued2012-09
dc.identifier.citationCHINESE JOURNAL OF ANALYTICAL CHEMISTRY,2012,40(9):1322-1328zh_CN
dc.identifier.issn0253-3820
dc.identifier.urihttp://dx.doi.org/10.1016/S1872-2040(11)60570-7
dc.identifier.uriWOS:000310570400001
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/14622
dc.description.abstractIn this study, serum and urine samples from 20 BC patients and 24 normal samples as control were collected. The biomarkers for bladder cancer were screened by metabonomics and profiled by liquid chromatography-electrospray ionization-mass spectrometry (LC-ESI/MS). The results showed BC patients were clearly distinguished from normal controls. 26 potential biomarkers were found out in serum and urine (13 each) using multivariate statistical analysis. Most of the potential biomarkers are common biomarkers existing in other diseases, however for the first time, to our knowledge, docosatrienol, azaprostanoic acid, and eicosatrienol were discovered in serum, and these new discovered biomarkers exhibit a huge potential for BC diagnosing. It is suggested that liquid chromatography-mass spectrometry (LC-MS) based metabonomics with multivariate statistical analysis can be applied in human BC detection.zh_CN
dc.description.sponsorshipNational Science Foundation for Fostering Talents in Basic Research of the National Natural Science Foundation of China [J1030415]; Fujian Province Department of Science & Technology, China [2009D023]zh_CN
dc.language.isoenzh_CN
dc.publisherELSEVIER SCIENCE INCzh_CN
dc.subjectBladder cancerzh_CN
dc.subjectMetabonomicszh_CN
dc.subjectLiquid chromatography-mass spectrometryzh_CN
dc.subjectSerum; Urinezh_CN
dc.titleA Study of Human Bladder Cancer by Serum and Urine Metabonomicszh_CN
dc.typeArticlezh_CN


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