Recent Submissions

  • Efficacy, Safety, and Immunogenicity of an Escherichia coliProduced Bivalent Human Papillomavirus Vaccine: An Interim Analysis of a Randomized Clinical Trial 

    You-Lin Qiao; 乔友林; Ting Wu; 吴婷; Rong-Cheng Li; 李荣成; Yue-Mei Hu; 胡月梅; Li-Hui Wei; 魏丽惠; Chang-Gui Li; 李长贵; Wen Chen; 陈汶; Shou-Jie Huang; Fang-Hui Zhao; Ming-Qiang Li; Qin-Jing Pan; Xun Zhang; Qing Li; Ying Hong; Chao Zhao; Wen-Hua Zhang; Yan-Ping Li; Kai Chu; Mei Li; Yun-Fei Jiang; Juan Li; Hui Zhao; Zhi-Jie Lin; Xue-Lian Cui; Wen-Yu Liu; Cai-Hong Li; Dong-Ping Guo; Li-Dong Ke; Xin Wu; Jie Tang; Guo-Qi Gao; Ba-Yi Li; Bin Zhao; Feng-Xian Zheng; Cui-Hong Dai; Meng Guo; Jun Zhao; Ying-Ying Su; Jun-Zhi Wang; Feng-Cai Zhu; Shao-Wei Li; Hui-Rong Pan; Yi-Min Li; Jun Zhang; 张军; Ning-Shao Xia; 夏宁邵 (Oxford University Press, 2019-05)
    【Abstract】Background The high cost and insufficient supply of human papillomavirus (HPV) vaccines have slowed the pace of controlling cervical cancer. A phase 3 clinical trial was conducted to evaluate the efficacy, safety ...
  • A unique B cell epitope-based particulate vaccine shows effective suppression of hepatitis B surface antigen in mice 

    Tian-Ying Zhang; 张天英; Xue-Ran Guo; 郭雪染; Yang-Tao Wu; 巫洋涛; Xiao-Zhen Kang; Qing-Bing Zheng; Ruo-Yao Qi; Bin-Bing Chen; Ying Lan; Min Wei; Shao-Juan Wang; Hua-Long Xiong; Jia-Li Cao; Bao-Hui Zhang; Xiao-Yang Qiao; Xiao-Fen Huang; Ying-Bin Wang; Mu-Jin Fang; Ya-Li Zhang; Tong Cheng; Yi-Xin Chen; Qin-Jian Zhao; Shao-Wei Li; Sheng-Xiang Ge; Pei-Jer Chen; Jun Zhang; 张军; Quan Yuan; 袁权; Ning-Shao Xia; 夏宁邵 (BMJ Publishing Group Ltd & British Society of Gastroenterology, 2019-03)
    【Abstract】Objective: This study aimed to develop a novel therapeutic vaccine based on a unique B cell epitope and investigate its therapeutic potential against chronic hepatitis B (CHB) in animal models. Methods: A ...
  • HBV infection-induced liver cirrhosis development in dual-humanized mice with human bone mesenchymal stem cell transplantation 

    Lunzhi Yuan; 袁伦志; Jing Jiang; 江静; Xuan Liu; 刘旋; Yali Zhang; Liang Zhang; Jiaojiao Xin; Kun Wu; Xiaoling Li; Jiali Cao; Xueran Guo; Dongyan Shi; Jun Li; Longyan Jiang; Suwan Sun; Tengyun Wang; Wangheng Hou; Tianying Zhang; Hua Zhu; Jun Zhang; Quan Yuan; Tong Cheng; 程通; Jun Li; 李君; Ningshao Xia; 夏宁邵 (BMJ Publishing Group Ltd & British Society of Gastroenterology, 2019-01)
    【Abstract】Objective: Developing a small animal model that accurately delineates the natural history of hepatitis B virus (HBV) infection and immunopathophysiology is necessary to clarify the mechanisms of host-virus ...
  • Rational design of a triple-type human papillomavirus vaccine by compromising viral-type specificity 

    Zhihai Li; 李智海; Shuo Song; 宋硕; Maozhou HE; 何茂洲; Daning Wang; Jingjie Shi; Xinlin Liu; Yunbing Li; Xin Chi; Shuangping Wei; Yurou Yang; Zhiping Wang; Jinjin Li; Huilian Qian; Hai Yu; Qingbing Zheng; Xiaodong Yan; Qinjian Zhao; Jun Zhang; Ying Gu; 顾颖; Shaowei Li; 李少伟; Ningshao Xia; 夏宁邵 (Nature Research (part of Springer Nature), 2018-12)
    【Abstract】Sequence variability in surface-antigenic sites of pathogenic proteins is an important obstacle in vaccine development. Over 200 distinct genomic sequences have been identified for human papillomavirus (HPV), of ...
  • Atomic structures of enterovirus D68 in complex with two monoclonal antibodies define distinct mechanisms of viral neutralization 

    Qingbing Zheng; 郑清炳; Rui Zhu; 朱瑞; Longfa Xu; 徐龙发; Maozhou He; 何茂洲; Xiaodong Yan; 颜晓东; Dongxiao Liu; Zhichao Yin; Yangtao Wu; Yongchao Li; Lisheng Yang; Wangheng Hou; Shuxuan Li; Zizhen Li; Zhenqin Chen; Zhihai Li; Hai Yu; Ying Gu; Jun Zhang; Timothy S.Baker; Z.Hongzhou; Barney S.Graham; Tong Cheng; 程通; Shaowei Li; 李少伟; Ningshao Xia; 夏宁邵 (Springer Nature Limited, 2018-11)
    【Abstract】Enterovirus D68 (EV-D68) undergoes structural transformation between mature, cell-entry intermediate (A-particle) and empty forms throughout its life cycle. Structural information for the various forms and ...
  • 2005~2014年厦门市鼻咽癌死亡特征与趋势分析 

    林艺兰; 池家煌; 龚永燕 (2016-03-10)
    目的探讨厦门市居民鼻咽癌死亡变化趋势,为厦门市鼻咽癌综合防治工作提供依据。方法收集整理2005~2014年厦门市居民鼻咽癌死亡资料,计算死亡率等评价指标,用多因素logistic回归分析鼻咽癌死亡的影响因素。结果 2005~2014年,厦门市居民鼻咽癌死亡率2.31/10万,男性死亡率是女性的2.64倍;死亡率随着年龄的增加逐渐升高,死亡年龄中位数为57岁,10年间死亡率处于较平稳水平(P>0.05)。男性(OR=2.95,95%CI: ...
  • 广西柳州18~45岁女性人乳头瘤病毒16/18型中和抗体流行率及其与宫颈病变相关性的研究 

    赵骏; 吴昕; 崔雪莲; 李晴; 陶华; 潘秦镜; 张询; 陈汶; 李艳萍; 李荣成; 黄守杰; 吴婷; 黎明强 (2017)
    阐明广西柳州地区自然人群中18~45岁女性人乳头瘤病毒(HPV)16/18型中和抗体和DNA流行情况,并探讨其与子宫颈癌癌前病变的相关性。201; 3年3月至7月在柳州市招募2; 300名18~45岁女性,采集血清以假病毒中和试验(PBNA)法检测HPV16/18型中和抗体,同时采集宫颈脱落细胞进行液基细胞学诊断和HPV; DNA检测,对细胞学异常者进行阴道镜检查,并对采集的组织学标本进行病理诊断。采用趋势性chi~2检验分析不同年龄段HPV; ...
  • 2005~2014年厦门市居民白血病死亡特征与趋势分析 

    林艺兰; 池家煌; 龚永燕 (2016-03-10)
    目的探讨厦门市居民白血病死亡变化趋势,为厦门市白血病综合防治工作提供依据。方法收集整理2005~2014年厦门市居民白血病死亡资料,计算死亡率等评价指标,用多因素logistic回归分析白血病死亡的影响因素。结果 2005~2014年,厦门市居民白血病死亡率3.62/10万,男性死亡率是女性的1.38倍;0~4岁组白血病死亡率较高,之后在较低水平波动,55岁后随着年龄的升高死亡率迅速升高;死亡年龄中位数为54岁,10年间死亡率处于较平稳 ...
  • 轮状病毒VP4亚单位疫苗研究进展 

    贾连智; 李廷栋; 葛胜祥 (2017-07-25)
    轮状病毒是全球范围内导致5岁以下婴幼儿严重腹泻的主要病原体,造成了巨大的经济负担和社会负担。疫苗预防接种是控制轮状病毒感染最为有效的手段,但在轮; 状病毒导致的死亡率较高的非洲和亚洲部分低收入国家,目前已经上市的轮状病毒疫苗的有效性较低,且会增加肠套叠的风险。更加安全、有效的轮状病毒疫苗对于; 降低轮状病毒感染导致的发病率和死亡率具有重要意义。目前,各国科研人员试图从多个方面提高轮状病毒疫苗的有效性,非复制型基因工程亚单位疫苗是目前轮状; ...
  • 蛋白磷酸酶2A调控细胞周期发挥抗肿瘤作用的研究进展 

    庄群瑛; 林育纯; 林忠宁 (2016-03-24)
    蛋白磷酸酶2A(PP2A)是真核细胞内广泛表达的丝氨酸/苏氨酸蛋白磷酸酶家族的主要成员,参与细胞周期、增殖分化及凋亡等过程中信号通路的去磷酸化调控。研究表明,PP2A不同亚基表达调控与人群肿瘤风险存在关联性;PP2A与细胞周期相关激酶相互作用,二者调控平衡的研究有助于致癌机制的探讨和靶向PP2A抗肿瘤作用的探索。本文对PP2A调控细胞周期的研究进行综述,着重阐述PP2A-B亚基经由细胞周期因子依赖性激酶1(CDK1)调控细胞周期发挥抑癌 ...

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