Now showing items 1-3 of 3
APP Regulates NGF Receptor Trafficking and NGF-Mediated Neuronal Differentiation and Survival
(PUBLIC LIBRARY SCIENCE, 2013-Nov 1)
beta-amyloid precursor protein (APP) is a key factor in Alzheimer's disease (AD) but its physiological function is largely undetermined. APP has been found to regulate retrograde transport of nerve growth factor (NGF), ...
CutA Divalent Cation Tolerance Homolog (Escherichia coli) (CUTA) Regulates beta-Cleavage of beta-Amyloid Precursor Protein (APP) through Interacting with beta-Site APP Cleaving Protein 1 (BACE1)
(AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 2012-03-30)
Background: The function of the CutA divalent cation tolerance homolog (Escherichia coli) (CUTA) is largely unknown. Results: CUTA has several isoforms, and the longest interacts with BACE1, regulates intracellular trafficking ...
Presenilins and gamma-secretase inhibitors affect intracellular trafficking and cell surface localization of the gamma-secretase complex components
The intramembranous cleavage of Alzheimer beta-amyloid precursor protein and the signaling receptor Notch is mediated by the presenilin (PS, PS1/PS2)-gamma-secretase complex, the components of which also include nicastrin, ...