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APP Regulates NGF Receptor Trafficking and NGF-Mediated Neuronal Differentiation and Survival
(PUBLIC LIBRARY SCIENCE, 2013-Nov 1)
beta-amyloid precursor protein (APP) is a key factor in Alzheimer's disease (AD) but its physiological function is largely undetermined. APP has been found to regulate retrograde transport of nerve growth factor (NGF), ...
Estrogen, beta-amyloid metabolism/trafficking, and Alzheimer‘s disease
Estrogen plays key regulatory roles in a variety of biological actions besides its classic function as a sex hormone. Recently, estrogen has been linked to neurodegenerative diseases including Alzheimer's disease (AD) and ...
Molecular and cellular mechanisms for Alzheimer‘s disease: Understanding APP metabolism
Alzheimer's disease (AD) is the most common neurodegenerative disease associated with aging. One important pathologic feature of AD is the formation of extracellular senile plaques in the brain, whose major components are ...
APP processing in Alzheimer's disease
An important pathological feature of Alzheimer's disease (AD) is the presence of extracellular senile plaques in the brain. Senile plaques are composed of aggregations of small peptides called beta-amyloid (A beta). Multiple ...