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APP Regulates NGF Receptor Trafficking and NGF-Mediated Neuronal Differentiation and Survival
(PUBLIC LIBRARY SCIENCE, 2013-Nov 1)
beta-amyloid precursor protein (APP) is a key factor in Alzheimer's disease (AD) but its physiological function is largely undetermined. APP has been found to regulate retrograde transport of nerve growth factor (NGF), ...
CutA Divalent Cation Tolerance Homolog (Escherichia coli) (CUTA) Regulates beta-Cleavage of beta-Amyloid Precursor Protein (APP) through Interacting with beta-Site APP Cleaving Protein 1 (BACE1)
(AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 2012-03-30)
Background: The function of the CutA divalent cation tolerance homolog (Escherichia coli) (CUTA) is largely unknown. Results: CUTA has several isoforms, and the longest interacts with BACE1, regulates intracellular trafficking ...
Intracellular Trafficking of Presenilin 1 Is Regulated by beta-Amyloid Precursor Protein and Phospholipase D1
(2009-05-01)
Excessive accumulation of beta-amyloid peptides in the brain is a major cause for the pathogenesis of Alzheimer disease. beta-Amyloid is derived from beta-amyloid precursor protein (APP) through sequential cleavages by ...
Presenilins and gamma-secretase inhibitors affect intracellular trafficking and cell surface localization of the gamma-secretase complex components
(2004)
The intramembranous cleavage of Alzheimer beta-amyloid precursor protein and the signaling receptor Notch is mediated by the presenilin (PS, PS1/PS2)-gamma-secretase complex, the components of which also include nicastrin, ...
Estrogen, beta-amyloid metabolism/trafficking, and Alzheimer‘s disease
(2006)
Estrogen plays key regulatory roles in a variety of biological actions besides its classic function as a sex hormone. Recently, estrogen has been linked to neurodegenerative diseases including Alzheimer's disease (AD) and ...
Estrogen, beta-amyloid metabolism/trafficking, and Alzheimer's disease
(2006)
Estrogen plays key regulatory roles in a variety of biological actions besides its classic function as a sex hormone. Recently, estrogen has been linked to neurodegenerative diseases including Alzheimer's disease (AD) and ...
Molecular and cellular mechanisms for Alzheimer's disease: Understanding APP metabolism
(2007)
Alzheimer's disease (AD) is the most common neurodegenerative disease associated with aging. One important pathologic feature of AD is the formation of extracellular senile plaques in the brain, whose major components are ...
Molecular and cellular mechanisms for Alzheimer‘s disease: Understanding APP metabolism
(2007)
Alzheimer's disease (AD) is the most common neurodegenerative disease associated with aging. One important pathologic feature of AD is the formation of extracellular senile plaques in the brain, whose major components are ...
APP processing in Alzheimer's disease
(2011-01-07)
An important pathological feature of Alzheimer's disease (AD) is the presence of extracellular senile plaques in the brain. Senile plaques are composed of aggregations of small peptides called beta-amyloid (A beta). Multiple ...