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APP Regulates NGF Receptor Trafficking and NGF-Mediated Neuronal Differentiation and Survival 

Zhang, Yun-Wu; Chen, Yaomin; Liu, Yun; Zhao, Yingjun; Liao, Francesca-Fang; Xu, Huaxi; 张云武 (PUBLIC LIBRARY SCIENCE, 2013-Nov 1)
beta-amyloid precursor protein (APP) is a key factor in Alzheimer's disease (AD) but its physiological function is largely undetermined. APP has been found to regulate retrograde transport of nerve growth factor (NGF), ...
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CutA Divalent Cation Tolerance Homolog (Escherichia coli) (CUTA) Regulates beta-Cleavage of beta-Amyloid Precursor Protein (APP) through Interacting with beta-Site APP Cleaving Protein 1 (BACE1) 

Zhao, Yingjun; Wang, Yunshu; Hu, Jin; Zhang, Xian; Zhang, Yun-wu; 张云武 (AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 2012-03-30)
Background: The function of the CutA divalent cation tolerance homolog (Escherichia coli) (CUTA) is largely unknown. Results: CUTA has several isoforms, and the longest interacts with BACE1, regulates intracellular trafficking ...
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Intracellular Trafficking of Presenilin 1 Is Regulated by beta-Amyloid Precursor Protein and Phospholipase D1 

Liu, Y.; Zhang, Y. W.; Wang, X.; Zhang, H.; You, X. Q.; Liao, F. F.; Xu, H. X.; 张云武 (2009-05-01)
Excessive accumulation of beta-amyloid peptides in the brain is a major cause for the pathogenesis of Alzheimer disease. beta-Amyloid is derived from beta-amyloid precursor protein (APP) through sequential cleavages by ...
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Presenilins and gamma-secretase inhibitors affect intracellular trafficking and cell surface localization of the gamma-secretase complex components 

Wang, H.; Luo, W. J.; Zhang, Y. W.; Li, Y. M.; Thinakaran, G.; Greengard, P.; Xu, H.; 张云武 (2004)
The intramembranous cleavage of Alzheimer beta-amyloid precursor protein and the signaling receptor Notch is mediated by the presenilin (PS, PS1/PS2)-gamma-secretase complex, the components of which also include nicastrin, ...
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Estrogen, beta-amyloid metabolism/trafficking, and Alzheimer‘s disease 

Xu, Huaxi; Wang, Ruishan; Zhang, Yun-Wu; Zhang, Xue; 张云武 (2006)
Estrogen plays key regulatory roles in a variety of biological actions besides its classic function as a sex hormone. Recently, estrogen has been linked to neurodegenerative diseases including Alzheimer's disease (AD) and ...
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Estrogen, beta-amyloid metabolism/trafficking, and Alzheimer's disease 

Xu, H. X.; Wang, R. S.; Zhang, Y. W.; Zhang, X.; 张云武 (2006)
Estrogen plays key regulatory roles in a variety of biological actions besides its classic function as a sex hormone. Recently, estrogen has been linked to neurodegenerative diseases including Alzheimer's disease (AD) and ...
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Molecular and cellular mechanisms for Alzheimer's disease: Understanding APP metabolism 

Zhang, Y. W.; Xu, H. X.; 张云武 (2007)
Alzheimer's disease (AD) is the most common neurodegenerative disease associated with aging. One important pathologic feature of AD is the formation of extracellular senile plaques in the brain, whose major components are ...
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Molecular and cellular mechanisms for Alzheimer‘s disease: Understanding APP metabolism 

Zhang, Yun-Wu; Xu, Huaxi; 张云武 (2007)
Alzheimer's disease (AD) is the most common neurodegenerative disease associated with aging. One important pathologic feature of AD is the formation of extracellular senile plaques in the brain, whose major components are ...
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APP processing in Alzheimer's disease 

Zhang, Yun-Wu; Thompson, Robert; Zhang, Han; Xu, Huaxi; 张云武 (2011-01-07)
An important pathological feature of Alzheimer's disease (AD) is the presence of extracellular senile plaques in the brain. Senile plaques are composed of aggregations of small peptides called beta-amyloid (A beta). Multiple ...

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作者张云武 (9)Xu, Huaxi (4)Zhang, Y. W. (4)Zhang, Yun-Wu (4)Xu, H. X. (3)... View More主题
TRANS-GOLGI NETWORK (9)
BETA-PEPTIDE PRODUCTION (4)A- (3)ALZHEIMERS-DISEASE (3)AMYLOID-PRECURSOR-PROTEIN (3)... View MoreDate Issued2012 (1)2011 (1)2009 (1)2007 (2)2006 (2)2004 (1)

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