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Furocoumarin Derivatives from Radix Angelicae Dahuricae and Their Effects on RXR alpha Transcriptional Regulation
A novel furocoumarin derivative named oxyalloimperatorin (1), together with seventeen furocoumarins 2-18 were isolated from the radix of Angelica dahurica. The chemical structure of new metabolite was characterized by ...
Multiple pathways were involved in tubeimoside-1-induced cytotoxicity of HeLa cells
(J PROTEOMICS, 2011-12-21)
The Bolbostemma paniculatum (Maxim.) Franquet (Cucurbitaceae) is a Chinese herb with anticancer potential. Its main active component tubeimoside-1 (TBMS1), a triterpenoid saponin, was previously proved as a potent anticancer ...
Myrotheciumones: Bicyclic cytotoxic lactones isolated from an endophytic fungus of Ajuga decumbens
(PERGAMON-ELSEVIER SCIENCE LTD, 2014-06-01)
Two new bicyclic lactones, myrotheciumones A (1) and B (2) which possessed a rare ring-fusion system were isolated from Myrothecium roridum (M. roridum), an endophytic fungus of the medicinal herb plant Ajuga decumbens (A. ...
Structure Elucidation and Biological Activity of Two New Trichothecenes from an Endophyte, Myrothecium roridum
(AMER CHEMICAL SOC, 2014-06-25)
Worldwide, many different grains are infected by various fungi that may produce trichothecene mycotoxins. Fungi that produce trichothecenes, as well as the trichothecenes themselves, are potential problems for public health. ...
Fatty acids as natural specific inhibitors of the proto-oncogenic protein Shp2
Src homology-2 domain-containing protein tyrosine phosphatase (Shp2), a novel proto-oncogenic protein, is an important target in cancer therapy research. Approximately 2000 plant extracts were screened to find its natural ...
Endofin, a FYVE domain protein, interacts with Smad4 and facilitates transforming growth factor-beta signaling
Transforming growth factor-beta (TGF-beta) signaling is facilitated by scaffold proteins such as SARA (Smad anchor for receptor activation). Endofin, a member of the FYVE domain protein family, has been suggested to regulate ...