Browsing 生物医学研究院 by Author "Bu, Guojun"
Now showing items 1-3 of 3
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Alzheimer's beta-Secretase (BACE1) Regulates the cAMP/PKA/CREB Pathway Independently of beta-Amyloid
Chen, Yaomin; Huang, Xiumei; Zhang, Yun-wu; 张云武; Rockenstein, Edward; Bu, Guojun; Golde, Todd E.; Masliah, Eliezer; Xu, Huaxi; 许华曦 (SOC NEUROSCIENCE, 2012-08-15)beta-Amyloid protein (A beta), the major component of neuritic plaques in Alzheimer's disease (AD), is derived from proteolytic cleavages of the amyloid precursor protein (APP) by beta-site APP-cleaving enzyme 1 (BACE1) ... -
Appoptosin is a Novel Pro-Apoptotic Protein and Mediates Cell Death in Neurodegeneration
Zhang, Han; Zhang, Yun-wu; Chen, Yaomin; Huang, Xiumei; Zhou, Fangfang; Wang, Weiwei; Xian, Bo; Zhang, Xian; Masliah, Eliezer; Chen, Quan; Han, Jing-Dong J.; Bu, Guojun; Reed, John C.; Liao, Francesca (2012-10-31)Apoptosis is an essential cellular process in multiple diseases and a major pathway for neuronal death in neurodegeneration. The detailed signaling events/pathways leading to apoptosis, especially in neurons, require further ... -
Differential Regulation of Amyloid-beta Endocytic Trafficking and Lysosomal Degradation by Apolipoprotein E Isoforms
Li, Jie; Kanekiyo, Takahisa; Shinohara, Mitsuru; Zhang, Yunwu; LaDu, Mary Jo; Xu, Huaxi; Bu, Guojun; 张云武 (2012-12-28)Aggregation of amyloid-beta (A beta) peptides leads to synaptic disruption and neurodegeneration in Alzheimer disease (AD). A major A beta clearance pathway in the brain is cellular uptake and degradation. However, how A ...