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dc.contributor.authorLiu, Liangpo
dc.contributor.authorXia, Tongwei
dc.contributor.authorGuo, Lihua
dc.contributor.authorCao, Lanyu
dc.contributor.authorZhao, Benhua
dc.contributor.author赵本华
dc.contributor.authorZhang, Jie
dc.contributor.authorDong, Sijun
dc.contributor.authorShen, Heqing
dc.date.accessioned2013-01-04T08:08:15Z
dc.date.available2013-01-04T08:08:15Z
dc.date.issued2012-11
dc.identifier.citationJOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY,2012,22(6):625-631zh_CN
dc.identifier.issn1559-0631
dc.identifier.urihttp://dx.doi.org/10.1038/jes.2012.51
dc.identifier.uriWOS:000309989900011
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/14314
dc.description.abstractThe urinary metabolites of phthalates are well-accepted exposure biomarkers for adults and children older than 6 years but are not commonly used for infants owing to non-convenient sampling. In the light of this situation, a novel sampling method based on monitoring the urine expressed from the gel diaper was developed. The urine was expressed from the gel absorbent after mixing the absorbent with CaCl2 and then collected by a laboratory-made device; the urinary phthalate metabolites were extracted and cleaned using a solid-phase extraction (SPE) column and analyzed with high-performance liquid chromatography-electrospray ionization-tandem mass spectrometry / mass spectrometry. To evaluate the method's feasibility, the following factors were investigated: the proportion of CaCl2 to gel absorbent, the urination volume variation and the target compounds' deposition bias in the diaper, the matrix blank of the different diaper brands, the storage stabilities and the recoveries of creatinine and phthalate metabolites in the expressed urine. Mono-methyl phthalate, mono-ethyl phthalate, mono-butyl phthalate, mono-benzyl phthalate, mono-2-ethylhexyl phthalate and mono-2-ethyl-5-oxohexyl phthalate were involved. 70-80% of the urine can be expressed from the diaper, and the expressed spiking recoveries and the limit of detection of mono-phthalates ranged from 88.5-115% and 0.21-0.50 ng/ml. The method was applied to measure phthalate metabolites in 65 gel diaper samples from 15 infants, and the pilot data suggests the infants are commonly exposed to phthalates. In summary, the method for monitoring of infant exposure to phthalates is sound and validated, and the potential health effects from the vulnerable infants' exposure to phthalates should be concerned.zh_CN
dc.description.sponsorship39th Scientific Research Foundation for the Returned Overseas Chinese Scholars (SRF for ROCS); Hundred Talent Program of Chinese Academy of Sciences (CAS); CAS/SAFEA International Partnership Program for Creative Research Teams [KZCX2-YW-T08]zh_CN
dc.language.isoenzh_CN
dc.publisherNATURE PUBLISHING GROUPzh_CN
dc.subjectbiomonitoringzh_CN
dc.subjectinfant exposurezh_CN
dc.subjectphthalateszh_CN
dc.subjectgel diaperzh_CN
dc.titleExpressing urine from a gel disposable diaper for biomonitoring using phthalates as an examplezh_CN
dc.typeArticlezh_CN


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