Production of Polyethylene Glycol Microparticles Using a SAS-Atomization Drying Process
- 化学化工－已发表论文 
超临界流体抗溶剂-雾化(SAS-A)技术研究用聚乙二醇(PEG6000)/乙醇/水体系制备聚乙二醇(PEG)微粒。探讨预膨胀压力、溶液浓度和溶液流量等工艺参数对微粒形貌及粒径的影响;重点探讨SAS-A技术中使用不同溶剂对颗粒形态和粒径分布的影响。结果表明,以丙酮和乙醇为溶剂的SAS-A技术可以制得形态基本上为球形的PEG微粒,粒径分布分别可以控制在1~5μm和2~15μm之间;增大预膨胀压力容易得到分散的球形微粒,并能减小微粒粒径,微粒粒径分布也随之变窄。对应PEG/丙酮体系,溶液浓度升高,所得到的微粒粒径增大;对应PEG/乙醇体系,溶液浓度对粒径大小影响不大,但溶液浓度增大会使粒径分布变宽。采用乙醇水溶液为溶剂时,初始乙醇浓度越低,移出水的效果越差,易形成结块的不规则微粒。Supercritical anti-solvent (SAS)-atomization process was employed to produce Polyethylene Glycol particles from PEG6000/ethanol/water solutions. The effect of different process parameters on the morphology and the size of the produced PEG particles, including the operating pressure, the protein concentration and the flow-rate of the protein/ethanol/water feed had been studied, especially the influence of various solvents were evaluated. The PEG particles produced form acetone and ethanol were generally spherical and with sizes of 1-5μm and 2-15μm respectively. Increasing pre-expansion pressure produced spherical and discrete particles with small size and narrow size distribution. Increasing the PEG concentration in acetone could evidently increase the PEG particle sizes and widen the particle size distribution while in ethanol the PEG particle sizes were changeless. Decreasing the concentration of ethanol in ethanol/water solution generated the particles irregular and agglomerated as water removal was limited.