Synthesis and Antibacterial Activity of Trans-but-2-enedioic Acid Bis-aromatic Alcohol Ester
- 化学化工－已发表论文 
本文合成了一系列的反丁烯二酸芳香醇(苄醇、苯乙醇、苯丙醇、邻溴苄醇)酯,所得产物的NMR、FTIR表征结果与理论预测一致。用光电比浊法研究其抑菌活性,反丁烯二酸芳香醇酯表现出较强的抑菌活性,随着芳香醇的链长的增加对四种细菌的抑制作用也增强,芳香醇卤代后,与反丁烯二酸所生成的二酯的抑菌作用也得到加强。反丁烯二酸芳香醇酯有望成为高效抑菌剂。A series of trans-but-2-enedioic acid bis-aromatic alcohol ester have been firstly synthesized by direct reaction of trans-but-2-enedioic acid with aromatic alcohol. The products were characterized with 1H NMR and FTIR. All the characterization data are consistent with the theoretic compositions and structures. The antibacterial activities against Bacillus subitilis,Mycococcus tetragenus Krasil' nikov,Staphylococcus aureus and Escherichia coli were tested by the method of phototurbidometry. All of the derivatives showed strong antibacterial activity against bacteria tested. The antibacterial activities of the derivatives were more effective with longer chain of the aromatic alcohol and halogenated with halide. It showed that the derivatives are potent and promising antibacterial agents.