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Requirement of the phosphatidylinositol 3-kinase/Akt signaling pathway for the effect of nicotine on interleukin-1beta-induced chondrocyte apoptosis in a rat model of osteoarthritis
(BIOCHEM BIOPH RES CO, 2012-07-06)
Chondrocyte apoptosis is mainly responsible for the progressive degeneration of cartilage in osteoarthritis (OA). Interleukin-1beta (IL-1 beta) was widely used as a modulating and chondrocyte apoptosis-inducing agent. ...