Now showing items 1-5 of 5
SERPINA3K Protects against Oxidative Stress via Modulating ROS Generation/Degradation and KEAP1-NRF2 Pathway in the Corneal Epithelium
(ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2012-07)
PURPOSE. We recently reported that SERPINA3K (SA3K), a member of the serine proteinase inhibitor (SERPIN) family, has antiangiogenic and anti-inflammatory activities. Here we investigated the antioxidant effects of SA3K ...
Therapeutic Effects of Epidermal Growth Factor on Benzalkonium Chloride-Induced Dry Eye in a Mouse Model
(INVEST OPHTH VIS SCI, 2012-01)
PURPOSE. To investigate the therapeutic effects and possible mechanisms of epidermal growth factor (EGF) on the mouse dry eye model induced by benzalkonium chloride (BAC). METHODS. The eye drop containing EGF was topically ...
Oxygen Tension Affects Terminal Differentiation of Corneal Limbal Epithelial Cells
(J CELL PHYSIOL, 2011-09)
Oxygen concentration has been shown to be crucial in the proliferation and differentiation of various types of cells, while the impact of oxygen tension on the lineage commitment of epithelial cells remains elusive. In ...
Modulation of the canonical Wnt pathway by Benzalkonium Chloride in corneal epithelium
(EXP EYE RES, 2011-10)
Benzalkonium Chloride (BAC) is commonly used in eyedrops. Although the cytotoxicity of BAC has been reported, the mechanism underlying its toxic effect has not been elucidated. The present study investigated the role of ...
Regulation of Endothelial Progenitor Cell Release by Wnt Signaling in Bone Marrow
(ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2013)
PURPOSE. Endothelial progenitor cells (EPC) have been shown to participate in ischemia-induced retinal neovascularization (NV). Overactivation of Wnt signaling has a pathogenic role in ischemia-induced retinal NV. The ...