Now showing items 131-136 of 136
New Method to Prepare Mitomycin C Loaded PLA-Nanoparticles with High Drug Entrapment Efficiency
The classical utilized double emulsion solvent diffusion technique for encapsulating water soluble Mitomycin C (MMC) in PLA nanoparticles suffers from low encapsulation efficiency because of the drug rapid partitioning to ...
Cytotoxic effects and the mechanism of three types of magnetic nanoparticles on human hepatoma BEL-7402 cells
The evaluation of the toxicity of magnetic nanoparticles (MNPs) has attracted much attention in recent years. The current study aimed to investigate the cytotoxic effects of Fe(3)O(4), oleic acid-coated Fe(3)O(4) (OA-Fe(3)O(4)), ...
【中文摘要】合成了生物素化壳聚糖（Bio-CS)，并通过核磁共振（1H NMR)及电感耦合等离子体光质谱法（ICP-MS）对其进行结构确证。采用溶剂挥发法（W1/O/W2）制备聚乳酸-羟基乙醇酸（PLGA)纳米粒，并通过共价交联法对纳米粒进行Bio-CS表面修饰。未修饰的PLGA纳米粒在扫描电镜下观察呈规则球状形态，平均粒径为（248.4±21.0）nm，Zeta电势为-（21.21±2.13）mV，Bio-CS修饰后的PLGA纳米粒保 ...
Preparation of folate-modified pullulan acetate nanoparticles for tumor-targeted drug delivery
The purpose of this work was to develop a novel nano-carrier with targeting property to tumor. In this study, pullulan acetate (PA) was synthesized by the acetylation of pullulan to simplify the preparation technique of ...
Stability and in vivo evaluation of pullulan acetate as a drug nanocarrier
To develop pullulan acetate nanoparticles (PANs) as a drug nanocarrier, pullulan acetate (PA) was synthesized and characterized. Its acetylation degree determined by the proton nuclear magnetic resonance ((1)H NMR) was ...