Now showing items 1-6 of 6
SERPINA3K Protects against Oxidative Stress via Modulating ROS Generation/Degradation and KEAP1-NRF2 Pathway in the Corneal Epithelium
(ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2012-07)
PURPOSE. We recently reported that SERPINA3K (SA3K), a member of the serine proteinase inhibitor (SERPIN) family, has antiangiogenic and anti-inflammatory activities. Here we investigated the antioxidant effects of SA3K ...
Adaptive influence of long term high altitude residence on spatial working memory: An fMRI study
(BRAIN COGNITION, 2011-10)
With an increasing population living at a high altitude (HA), the impact of HA residence on human cognitive function has raised concerns. We recruited two groups of college students with one group born and grew up at HA ...
Combination of monoclonal antibodies with DST inhibits accelerated rejection mediated by memory T cells to induce long-lived heart allograft acceptance in mice
(IMMUNOL LETT, 2011-08-30)
Donor-reactive memory T cells mediated accelerated rejection is known as a barrier to the survival of transplanted organs. We investigated the combination of different monoclonal antibodies (mAbs) and donor-specific ...
Electrophysiological Characteristics of a SCN5A Voltage Sensors Mutation R1629Q Associated With Brugada Syndrome
(PUBLIC LIBRARY SCIENCE, 2013-Oct 2)
Brugada syndrome (BrS) is an inherited arrhythmogenic syndrome leading to sudden cardiac death, partially associated with autosomal dominant mutations in SCN5A, which encodes the cardiac sodium channel alpha-subunit ...
Puerarin Alleviates Neuropathic Pain by Inhibiting Neuroinflammation in Spinal Cord
(HINDAWI PUBLISHING CORPORATION, 2014)
Neuropathic pain responds poorly to drug treatments, and partial relief is achieved in only about half of the patients. Puerarin, the main constituent of Puerariae Lobatae Radix, has been used extensively in China to treat ...
MEK inhibition reduces glial scar formation and promotes the recovery of sensorimotor function in rats following spinal cord injury
(SPANDIDOS PUBL LTD, 2014 JAN)
The aim of this study was to investigate the effect of U0126 on the formation of glial scars following spinal cord injury (SCI) in a rat model. Ninety adult female Sprague-Dawley rats were divided randomly into sham injury ...