Now showing items 1-3 of 3

    • CDK5-dependent BAG3 degradation modulates synaptic protein turnover 

      Jiechao Zhou; 周杰超; Hei-Man Chow; Yan Liu; Di Wu; Meng Shi; Jieyin Li; Lei Wen; Kai Zhuang; 文磊; Yuehong Gao; Guimiao Chen; Kai Zhuang; Hui Lin; Guanyun Zhang; Wenting Xie; Huifang Li; Lige Leng; Mengdan Wang; Naizhen Zheng; Hao Sun; Yingjun Zhao; 赵颖俊; Yunwu Zhang; 张云武; Maoqiang Xue; 薛茂强; Timothy Y. Huang; Guojun Bu; 卜国军; Huaxi Xu; 许华曦; Zengqiang Yuan; 袁增强; Karl Herrup; Jie Zhang; 张杰 (Elsevier B.V., 2019-11)
      Background Synaptic protein dyshomeostasis and functional loss is an early invariant feature of Alzheimer’s disease (AD), yet the unifying etiological pathway remains largely unknown. Knowing that cyclin-dependent kinase ...
    • Menin Deficiency Leads to Depressive-like Behaviors in Mice by Modulating Astrocyte-Mediated Neuroinflammation 

      Lige Leng; 冷历歌; Kai Zhuang; 庄恺; Zeyue Liu; 刘泽玥; Changquan Huang; Yuehong Gao; Guimiao Chen; Hui Lin; Yu Hu; Di Wu; Meng Shi; Wenting Xie; Hao Sun; Zhicheng Shao; Huifang Li; Kunkun Zhang; Wei Mo; 莫玮; Timothy Y. Huang; Maoqiang Xue; 薛茂强; Zengqiang Yuan; 袁增强; Xia Zhang; 张遐; Guojun Bu; 卜国军; Huaxi Xu; 许华曦; Qi Xu; Jie Zhang; 张杰 (Elsevier Inc., 2018-09-13)
      【Abstract】Astrocyte dysfunction and inflammation are associated with the pathogenesis of major depressive disorder (MDD). However, the mechanisms underlying these effects remain largely unknown. Here, we found that multiple ...
    • Neuron-Specific Menin Deletion Leads to Synaptic Dysfunction and Cognitive Impairment by Modulating p35 Expression 

      Kai Zhuang; 庄恺; Changquan Huang; Lige Leng; Honghua Zheng; Yuehong Gao; Guimiao Chen; Zhilin Ji; Hao Sun; Yu Hu; Di Wu; Meng Shi; Huifang Li; Yingjun Zhao; Yunwu Zhang; 张云武; Maoqiang Xue; Guojun Bu; 卜国军; Timothy Y. Huang; Huaxi Xu; 许华曦; Jie Zhang; 张杰 (Elsevier Inc., 2018-07-17)
      【Abstract】Menin (MEN1) is a critical modulator of tissue development and maintenance. As such, MEN1 mutations are associated with multiple endocrine neoplasia type 1 (MEN1) syndrome. Although menin is abundantly expressed ...