Now showing items 1-3 of 3

    • Interplay between Menin and K-Ras in Regulating Lung Adenocarcinoma 

      Wu, Yuan; Feng, Zi-Jie; Gao, Shu-Bin; Matkar, Smita; Xu, Bin; Duan, Hong-Bin; Lin, Xiao; Li, Shan-Hua; Hua, Xianxin; Jin, Guang-Hui; 金光辉 (J BIOL CHEM, 2012-11-16)
      MEN1, which encodes the nuclear protein menin, acts as a tumor suppressor in lung cancer and is often inactivated in human primary lung adenocarcinoma. Here, we show that the inactivation of MEN1 is associated with increased ...
    • Menin promotes hepatocellular carcinogenesis and epigenetically up-regulates Yap1 transcription 

      Xu, Bin; Li, Shan-Hua; Zheng, Rong; Gao, Shu-Bin; Ding, Li-Hong; Yin, Zhen-Yu; Lin, Xiao; Feng, Zi-Jie; Zhang, Sheng; Wang, Xiao-Min; Jin, Guang-Hui; 徐斌; 李善花; 郑荣; 丁丽红; 尹震宇; 冯子杰; 金光辉 (NATL ACAD SCIENCES, 2013-Oct 2)
      Menin is a scaffold protein encoded by the multiple endocrine neoplasia type 1 (MEN1) gene in humans, and it interacts with a variety of transcriptional proteins to control active or repressive cellular processes. Here, ...
    • Menin represses malignant phenotypes of melanoma through regulating multiple pathways 

      Gao, Shu-Bin; Feng, Zi-Jie; Xu, Bin; Chen, Yan; Zheng, Hong-Hua; Yin, Ping; Hua, Xianxin; Jin, Guang-Hui; 殷平 (J CELL MOL MED, 2011-09)
      Substantial genetic evidence suggests that chromosome 11q is involved in regulating initiation and progression of malignant melanomas. Mutations of the MEN1 gene, located in chromosome 11q13, predispose individuals to the ...