Now showing items 362-381 of 2443

    • EGF Reverses Multi-drug Resistance via the p-ERK Pathway in HepG2/ADM and SMMC7721/ADM Hepatocellular Carcinoma Models 

      Yan, Feng; Bai, Li-Ping; Gao, Hua; Zhu, Chang-Ming; Lin, Li; Kang, Xiang-Peng; 闫峰 (ASIAN PACIFIC ORGANIZATION CANCER PREVENTION, 2014)
      Aim: To investigate signaling pathways for reversal of EGF-mediated multidrug resistance (MDR) in hepatocellular carcinoma (HCC) models. Materials and Methods: HCC MDR cell strain HepG2/adriamycin (ADM) and SMMC7721/ADM ...
    • EGFR参与溶血磷脂酸诱导口腔鳞癌细胞整合素β6的表达 

      殷豪; 邓小玲; 李国阳; 石松林; 李祺福; 许铭炎 (2015-8-28)
      目的:探讨表皮生长因子受体(Egfr)在溶血磷脂酸(lPA)诱导口腔鳞癌细胞整合素β6(ITgb6)表达中的作用。方法:将口腔鳞癌细胞SAS接种到6孔板中,经lPA诱导后,收集细胞,用定量rT-PCr和WESTErn blOT检测ITgb6的MrnA和蛋白表达量;利用Egfr抑制剂Ag1478检测Egfr对lPA诱导ITgb6MrnA和蛋白表达的影响。结果:1)经10μMOl/l lPA诱导2H后,SAS细胞ITgb6的MrnA表达水平 ...
    • Electrically conductive poly(DL-lactide)/chitosan/polypyrrole complexes 

      Wan, Y.; Fang, Y.; Hu, Z. L.; Wu, Q.; 方亚 (2006-06-24)
      The fabrication of novel conductive poly(DL-lactide)/chitosan/polypyrrole complex membranes is reported. Using poly(DL-lactide)/chitosan blends as matrices and polypyrrole as a conductive component, several kinds of membranes ...
    • Electrophysiological Characteristics of a SCN5A Voltage Sensors Mutation R1629Q Associated With Brugada Syndrome 

      Zeng, Zhipeng; Zhou, Jieqiong; Hou, Yuxi; Liang, Xiaojing; Zhang, Ziguan; Xu, Xuejing; Xie, Qiang; Li, Weihua; Huang, Zhengrong; 周洁琼; 梁晓静; 谢强; 李卫华; 黄峥嵘 (PUBLIC LIBRARY SCIENCE, 2013-Oct 2)
      Brugada syndrome (BrS) is an inherited arrhythmogenic syndrome leading to sudden cardiac death, partially associated with autosomal dominant mutations in SCN5A, which encodes the cardiac sodium channel alpha-subunit ...
    • Electrostatic interaction in the NH2-terminus accelerates inactivation of the Kv14 channel 

      Fan, Zhuo; Bi, Li-jun; Jin, Gang; Qi, Zhi; 戚智 (BBA-BIOMEMBRANES, 2010-09)
      Inactivation of potassium channels plays an important role in shaping the electrical signalling properties of nerve and muscle cells. While it has been assumed that the rapid inactivation of the Kv1.4 channel is controlled ...
    • Electrosurgical Enucleation Versus Bipolar Transurethral Resection for Prostates Larger than 70 ml: A Prospective, Randomized Trial with 5-Year Followup 

      Zhu, Lingfeng; Chen, Shushang; Yang, Shunliang; Wu, Meijing; Ge, Rong; Wu, Weizhen; Liao, Lianming; Tan, Jianming; 杨顺良; 谭建明 (ELSEVIER SCIENCE INC, 2013)
      Purpose: We compared the perioperative and postoperative characteristics of prostate PlasmaKinetic (TM) enucleation and bipolar transurethral resection for large volume benign prostatic hyperplasia. Materials and Methods: ...
    • Emergence of resistance to fluoroquinolones and third-generation cephalosporins in Shigella flexneri subserotype 1c isolates from China 

      Qiu, S.; Xu, X.; Wang, Y.; Yang, G.; Wang, Z.; Wang, H.; Zhang, L.; Liu, N.; Chen, C.; Liu, W.; Li, J.; Su, W.; Jia, L.; Wang, L.; Jin, H.; Keim, P.; Yuan, Z.; Huang, L.; Song, H.; 王合; 张玲 (CLIN MICROBIOL INFEC, 2012-04)
      We report here on the first identification of Shigella flexneri subserotype 1c in China. We also report the emergence of resistance to ciprofloxacin and third-generation cephalosporins in this subserotype 1c for the first ...
    • Emergent Surgical Reduction and Fixation for Pipkin Type I Femoral Fractures 

      Lin, Dasheng; Lian, Kejian; Chen, Zhiwen; Wang, Lei; Hao, Jianming; Zhang, Huantang; 林达生; 练克俭; 陈志文 (SLACK INC, 2013)
      The purpose of this study was to assess the effect of timing of large fragment fixation in patients with Pipkin type-I fractures. Patients with Pipkin type-I fractures from the authors' trauma center were prospectively ...
    • EndoS Reduces the Pathogenicity of Anti-mCOL7 IgG through Reduced Binding of Immune Complexes to Neutrophils 

      Yu, Xinhua; Zheng, Junfeng; Collin, Mattias; Schmidt, Enno; Zillikens, Detlef; Petersen, Frank; 余新华 (PUBLIC LIBRARY SCIENCE, 2014-02-04)
      Endo-beta-N-acetylglucosaminidase (EndoS) has been shown to act as a potent pathogen-derived immunomodulatory molecule in autoimmune diseases. Here we investigated how EndoS treatment reduces the pathogenicity of rabbit ...
    • Endothelin-1 induces hypoxia inducible factor 1 alpha expression in pulmonary artery smooth muscle cells 

      Li, Manxiang; Liu, Yuan; Jin, Faguang; Sun, Xiuzhen; Li, Zongfang; Liu, Yun; Fang, Ping; Shi, Hongyang; Jiang, Xingtang; 江兴堂 (FEBS LETT, 2012-11-02)
      Endothelin-1 (ET-1) dose-dependently increased HIF1 alpha expression in pulmonary artery smooth muscle cells (PASMCs). Inhibition of protein synthesis did not affect ET-1-induced HIF1 alpha expression. The maximum effect ...
    • Enhanced drug loading capacity of polypyrrole nanowire network for controlled drug release 

      Jiang, Shuhui; Sun, Yanan; Cui, Xin; Huang, Xiang; He, Yuan; Ji, Shan; Shi, Wei; Ge, Dongtao; 孙亚楠; 黄翔; 石巍; 葛东涛 (ELSEVIER SCIENCE SA, 2013-Jan 1)
      For a conducting polymer (CP) based drug release system, drug loading is often accomplished by a doping process, in which drug is incorporated into polymer as dopant. Therefore, the drug loading capacity is relatively low ...
    • Enhanced production of pullulan in Aureobasidium pullulans by a new process of genome shuffling 

      方亚 (2011)
      Pullulan is a water-soluble extracelluler polysaccharide produced aerobically by fungus Aureobasidium pullulans and some other species. Current work focused on developing an A. pullulans strain with enhanced pullulan ...
    • Enhancement on electric responses of BaTiO3 particles with polymer-coating 

      Gao, Ling-xiang; Li, Li; Qi, Xiao-rong; Wei, Wen-xin; Hai, Jin-ling; Gao, Wei-qing; Gao, Zi-wei; 魏文鑫; 魏文欣 (WILEY-BLACKWELL, 2013)
      To enhance electric response by polymer coating, BaTiO3/polymer shellcore composite particles were prepared by emulsion polymerization with polyimide, chitosan, polystyrene, polyacrylic acid, and polyacrylamide. Their micro ...
    • eNOS/NO途径在单侧输尿管梗阻小鼠肾间质微血管病变中的作用与机制 

      陈雁; 牛潼; 白海涛; 杨晓晶; 张燕林; 羊钦裕 (2015-10-30)
      目的探讨内皮型一氧化氮合酶(EndOTHElIAl nITrIC OXIdE SynTHASE,E nOS)和一氧化氮(nITrIC OXIdE,nO)在单侧输尿管梗阻(unIlATErAl urETErAl ObSTruCTIOn,uuO)肾间质纤维化小鼠微血管病变中的作用及机制。方法64只kM小鼠随机分为两组:假手术组n=32只;单侧输尿管梗阻uuO组n=32只。观察4周,每周检测各组小鼠血bun、SCr及一氧化氮,流式细胞计数外周 ...
    • Environmental chemical stressors as epigenome modifiers: a new horizon in assessment of toxicological effects 

      Shen, Heqing; Martin, F. L.; Su, Yanhua; 苏艳华 (SCIENCE PRESS, 2014 FEB)
      In eukaryotic cells, chromatin transformation from euchromatin into heterochromatin as a means of controlling gene expression and replication has been known as the "accessibility hypothesis". The interplay of epigenetic ...
    • EphA2 enhances the proliferation and invasion ability of LNCaP prostate cancer cells 

      Chen, Peijie; Huang, Yan; Zhang, Bo; Wang, Qiuquan; Bai, Peiming; 陈培杰; 张博; 王秋泉; 白培明 (SPANDIDOS PUBL LTD, 2014 JUL)
      EphA2 is persistently overexpressed and functionally changed in numerous human cancers. However, to the best of our knowledge, the role that EphA2 plays in prostate cancer is not entirely clear. To investigate the roles ...
    • Epidemiology of Zoonotic Hepatitis E: A Community-Based Surveillance Study in a Rural Population in China 

      Zhu, Feng-Cai; Huang, Shou-Jie; Wu, Ting; Zhang, Xue-Feng; Wang, Zhong-Ze; Ai, Xing; Yan, Qiang; Yang, Chang-Lin; Cai, Jia-Ping; Jiang, Han-Min; Wang, Yi-Jun; Ng, Mun-Hon; Zhang, Jun; Xia, Ning-Shao; 吴婷; 张军; 夏宁邵 (PUBLIC LIBRARY SCIENCE, 2014-01-31)
      Background: Hepatitis E is caused by two viral genotype groups: human types and zoonotic types. Current understanding of the epidemiology of the zoonotic hepatitis E disease is founded largely on hospital-based studies. ...
    • ER-associated degradation regulates Alzheimer's amyloid pathology and memory function by modulating γ-secretase activity 

      Bing Zhu; LuLin Jiang; Timothy Huang; Yingjun Zhao; Tongfei Liu; Yongwang Zhong; Xiaoguang Li; Alexandre Campos; Kenneth Pomeroy; Eliezer Masliah; Dongxian Zhang; Huaxi Xu; 许华曦 (Macmillan Publishers Limited,part of Springer Nature, 2017-11)
      【Abstract】Endoplasmic-reticulum-associated degradation (ERAD) is an important protein quality control system which maintains protein homeostasis. Constituents of the ERAD complex and its role in neurodegeneration are not ...
    • ERCP对梗阻性黄疸病因的诊断价值 

      叶震世; 钟燕; 吴艳环; 郭明玉; 蔡志萍; 任建林 (2004-07-15)
      目的:探讨ERCP对梗阻性黄疸病因的诊断价值. 方法:对74例梗阻性黄疸行ERCP检查并与术后诊断比较,其中41例同时有ERCP,B超及CT检查,比较三者诊断的符合率. 结果:本组示恶性胆道梗阻36例,占48.6%;良性梗阻38 例,占51.4%.与术后诊断比较,ERCP对胆总管结石的诊断符合率96.9%.对恶肿瘤诊断符合率77.8%,主要是胰腺癌、胆管癌、胆囊癌及壶腹周围癌等.41例中ERCP对梗阻性黄疸病因的诊断率明显高于B超及CT(P<0.05). ...
    • ERK干扰质粒的构建及对胃癌细胞株BGC823 DcR3表达的影响 

      范鑫; 庄国洪; 黄小平; 杨东海; 刘彬; 程小峰; 刘忠臣 (2010-12-01)
      目的探讨胃癌发展的分子机制,通过构建ERK1/2shRNA真核表达载体,体外研究其对人胃癌细胞株BGC823ERK1/2蛋白及DcR3表达水平的影响。方法应用PRNAT-U6.1/Neo载体构建ERK1/2基因shRNA重组质粒,经脂质体法导入BGC823细胞中,分别设置对照组、干扰组和U0126抑制剂组。Westernblot法检测转染后BGC823细胞及抑制剂使用后ERK1/2蛋白的表达变化,荧光显微镜检测质粒自带GFP基因的表达情 ...