Now showing items 362-381 of 2317

    • Emergence of resistance to fluoroquinolones and third-generation cephalosporins in Shigella flexneri subserotype 1c isolates from China 

      Qiu, S.; Xu, X.; Wang, Y.; Yang, G.; Wang, Z.; Wang, H.; Zhang, L.; Liu, N.; Chen, C.; Liu, W.; Li, J.; Su, W.; Jia, L.; Wang, L.; Jin, H.; Keim, P.; Yuan, Z.; Huang, L.; Song, H.; 王合; 张玲 (CLIN MICROBIOL INFEC, 2012-04)
      We report here on the first identification of Shigella flexneri subserotype 1c in China. We also report the emergence of resistance to ciprofloxacin and third-generation cephalosporins in this subserotype 1c for the first ...
    • Emergent Surgical Reduction and Fixation for Pipkin Type I Femoral Fractures 

      Lin, Dasheng; Lian, Kejian; Chen, Zhiwen; Wang, Lei; Hao, Jianming; Zhang, Huantang; 林达生; 练克俭; 陈志文 (SLACK INC, 2013)
      The purpose of this study was to assess the effect of timing of large fragment fixation in patients with Pipkin type-I fractures. Patients with Pipkin type-I fractures from the authors' trauma center were prospectively ...
    • EndoS Reduces the Pathogenicity of Anti-mCOL7 IgG through Reduced Binding of Immune Complexes to Neutrophils 

      Yu, Xinhua; Zheng, Junfeng; Collin, Mattias; Schmidt, Enno; Zillikens, Detlef; Petersen, Frank; 余新华 (PUBLIC LIBRARY SCIENCE, 2014-02-04)
      Endo-beta-N-acetylglucosaminidase (EndoS) has been shown to act as a potent pathogen-derived immunomodulatory molecule in autoimmune diseases. Here we investigated how EndoS treatment reduces the pathogenicity of rabbit ...
    • Endothelin-1 induces hypoxia inducible factor 1 alpha expression in pulmonary artery smooth muscle cells 

      Li, Manxiang; Liu, Yuan; Jin, Faguang; Sun, Xiuzhen; Li, Zongfang; Liu, Yun; Fang, Ping; Shi, Hongyang; Jiang, Xingtang; 江兴堂 (FEBS LETT, 2012-11-02)
      Endothelin-1 (ET-1) dose-dependently increased HIF1 alpha expression in pulmonary artery smooth muscle cells (PASMCs). Inhibition of protein synthesis did not affect ET-1-induced HIF1 alpha expression. The maximum effect ...
    • Enhanced drug loading capacity of polypyrrole nanowire network for controlled drug release 

      Jiang, Shuhui; Sun, Yanan; Cui, Xin; Huang, Xiang; He, Yuan; Ji, Shan; Shi, Wei; Ge, Dongtao; 孙亚楠; 黄翔; 石巍; 葛东涛 (ELSEVIER SCIENCE SA, 2013-Jan 1)
      For a conducting polymer (CP) based drug release system, drug loading is often accomplished by a doping process, in which drug is incorporated into polymer as dopant. Therefore, the drug loading capacity is relatively low ...
    • Enhanced production of pullulan in Aureobasidium pullulans by a new process of genome shuffling 

      方亚 (2011)
      Pullulan is a water-soluble extracelluler polysaccharide produced aerobically by fungus Aureobasidium pullulans and some other species. Current work focused on developing an A. pullulans strain with enhanced pullulan ...
    • Enhancement on electric responses of BaTiO3 particles with polymer-coating 

      Gao, Ling-xiang; Li, Li; Qi, Xiao-rong; Wei, Wen-xin; Hai, Jin-ling; Gao, Wei-qing; Gao, Zi-wei; 魏文鑫; 魏文欣 (WILEY-BLACKWELL, 2013)
      To enhance electric response by polymer coating, BaTiO3/polymer shellcore composite particles were prepared by emulsion polymerization with polyimide, chitosan, polystyrene, polyacrylic acid, and polyacrylamide. Their micro ...
    • eNOS/NO途径在单侧输尿管梗阻小鼠肾间质微血管病变中的作用与机制 

      陈雁; 牛潼; 白海涛; 杨晓晶; 张燕林; 羊钦裕 (2015-10-30)
      目的探讨内皮型一氧化氮合酶(EndOTHElIAl nITrIC OXIdE SynTHASE,E nOS)和一氧化氮(nITrIC OXIdE,nO)在单侧输尿管梗阻(unIlATErAl urETErAl ObSTruCTIOn,uuO)肾间质纤维化小鼠微血管病变中的作用及机制。方法64只kM小鼠随机分为两组:假手术组n=32只;单侧输尿管梗阻uuO组n=32只。观察4周,每周检测各组小鼠血bun、SCr及一氧化氮,流式细胞计数外周 ...
    • Environmental chemical stressors as epigenome modifiers: a new horizon in assessment of toxicological effects 

      Shen, Heqing; Martin, F. L.; Su, Yanhua; 苏艳华 (SCIENCE PRESS, 2014 FEB)
      In eukaryotic cells, chromatin transformation from euchromatin into heterochromatin as a means of controlling gene expression and replication has been known as the "accessibility hypothesis". The interplay of epigenetic ...
    • EphA2 enhances the proliferation and invasion ability of LNCaP prostate cancer cells 

      Chen, Peijie; Huang, Yan; Zhang, Bo; Wang, Qiuquan; Bai, Peiming; 陈培杰; 张博; 王秋泉; 白培明 (SPANDIDOS PUBL LTD, 2014 JUL)
      EphA2 is persistently overexpressed and functionally changed in numerous human cancers. However, to the best of our knowledge, the role that EphA2 plays in prostate cancer is not entirely clear. To investigate the roles ...
    • Epidemiology of Zoonotic Hepatitis E: A Community-Based Surveillance Study in a Rural Population in China 

      Zhu, Feng-Cai; Huang, Shou-Jie; Wu, Ting; Zhang, Xue-Feng; Wang, Zhong-Ze; Ai, Xing; Yan, Qiang; Yang, Chang-Lin; Cai, Jia-Ping; Jiang, Han-Min; Wang, Yi-Jun; Ng, Mun-Hon; Zhang, Jun; Xia, Ning-Shao; 吴婷; 张军; 夏宁邵 (PUBLIC LIBRARY SCIENCE, 2014-01-31)
      Background: Hepatitis E is caused by two viral genotype groups: human types and zoonotic types. Current understanding of the epidemiology of the zoonotic hepatitis E disease is founded largely on hospital-based studies. ...
    • ER-associated degradation regulates Alzheimer's amyloid pathology and memory function by modulating γ-secretase activity 

      Bing Zhu; LuLin Jiang; Timothy Huang; Yingjun Zhao; Tongfei Liu; Yongwang Zhong; Xiaoguang Li; Alexandre Campos; Kenneth Pomeroy; Eliezer Masliah; Dongxian Zhang; Huaxi Xu; 许华曦 (Macmillan Publishers Limited,part of Springer Nature, 2017-11)
      【Abstract】Endoplasmic-reticulum-associated degradation (ERAD) is an important protein quality control system which maintains protein homeostasis. Constituents of the ERAD complex and its role in neurodegeneration are not ...
    • ERCP对梗阻性黄疸病因的诊断价值 

      叶震世; 钟燕; 吴艳环; 郭明玉; 蔡志萍; 任建林 (2004-07-15)
      目的:探讨ERCP对梗阻性黄疸病因的诊断价值. 方法:对74例梗阻性黄疸行ERCP检查并与术后诊断比较,其中41例同时有ERCP,B超及CT检查,比较三者诊断的符合率. 结果:本组示恶性胆道梗阻36例,占48.6%;良性梗阻38 例,占51.4%.与术后诊断比较,ERCP对胆总管结石的诊断符合率96.9%.对恶肿瘤诊断符合率77.8%,主要是胰腺癌、胆管癌、胆囊癌及壶腹周围癌等.41例中ERCP对梗阻性黄疸病因的诊断率明显高于B超及CT(P<0.05). ...
    • ERK干扰质粒的构建及对胃癌细胞株BGC823 DcR3表达的影响 

      范鑫; 庄国洪; 黄小平; 杨东海; 刘彬; 程小峰; 刘忠臣 (2010-12-01)
      目的探讨胃癌发展的分子机制,通过构建ERK1/2shRNA真核表达载体,体外研究其对人胃癌细胞株BGC823ERK1/2蛋白及DcR3表达水平的影响。方法应用PRNAT-U6.1/Neo载体构建ERK1/2基因shRNA重组质粒,经脂质体法导入BGC823细胞中,分别设置对照组、干扰组和U0126抑制剂组。Westernblot法检测转染后BGC823细胞及抑制剂使用后ERK1/2蛋白的表达变化,荧光显微镜检测质粒自带GFP基因的表达情 ...
    • Establishment of a Functional Cell Line Expressing both Subunits of H1a and H2c of Human Hepatocyte Surface Molecule ASGPR 

      Hu, Bin; Yang, Yan; Liu, Jia; Ma, Zhiyong; Huang, Hongping; Liu, Shenpei; Yu, Yuan; Hao, Youhua; Wang, Baoju; Lu, Mengji; Yang, Dongliang; 胡斌 (J HUAZHONG U SCI-MED, 2010-10)
      To better understand the effect of a new split variant of human asialoglycoprotein receptor (ASGPR H1b) on ASGPR ligands' binding ability, we established a functional cell line which expresses ASGPR. The full lengths of ...
    • Establishment of a Molecular Diagnostic System for Spinal Muscular Atrophy Experience From a Clinical Laboratory in China 

      Zeng, Jian; Lin, Yanhong; Yan, Aizhen; Ke, Longfeng; Zhu, Zhongyong; Lan, Fenghua; 兰风华 (J MOL DIAGN, 2011-01)
      Spinal muscular atrophy (SMA) is a common autosomal recessive neuromuscular disorder characterized by degeneration of the anterior horn of the spinal cord. The disease gene survival motor neuron 1 (SMN1) is homozygously ...
    • Ether a go-go 1 Silencing in Combination with TRAIL Overexpression Has Synergistic Antitumor Effects on Osteosarcoma 

      Wu, Jin; Zeng, Tian; Wu, Xinyu; Gao, Quan; Zhai, Wenliang; Ding, Zhenqi; 吴欣宇 (MARY ANN LIEBERT INC, 2013)
      Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has been utilized for cancer therapy, but the resistance of cancer cells to TRAIL remains an obstacle. Ether a go-go 1 (Eag1) channel is overexpressed in a ...
    • Ethylenediaminetetraacetic acid as capping ligands for highly water-dispersible iron oxide particles 

      Yi, Yunfeng; Zhang, Ying; Wang, Yixiao; Shen, Lihua; Jia, Mengmeng; Huang, Yu; Hou, Zhenqing; Zhuang, Guo; 黄宇; 张颖; 侯振清; 庄国洪 (SPRINGER, 2014)
      Monodispersed magnetite (Fe3O4) particles were synthesized using a high-temperature hydrolysis reaction with the assistance of ethylenediaminetetraacetic acid (EDTA) as capping ligands.These particles were composed of small ...
    • Evaluation of a colloidal gold immunochromatography assay in the detection of Treponema pallidum specific IgM antibody in syphilis serofast reaction patients: a serologic marker for the relapse and infection of syphilis 

      Lin, Li-Rong; Tong, Man-Li; Fu, Zuo-Gen; Dan, Bing; Zheng, Wei-Hong; Zhang, Chang-Gong; Yang, Tian-Ci; Zhang, Zhong-Ying; 林丽蓉; 郑维红; 杨天赐; 张忠英 (DIAGN MICR INFEC DIS, 2011-05)
      Syphilis remains as a worldwide public health problem; hence, it is necessary to develop a new diagnostic approach that is easier and faster than conventional tests. A new testing method to detect Treponema pallidum IgM ...
    • Evaluation of Age-Related Changes in Noninvasive Tear Breakup Time 

      Hong, Jiaxu; Liu, Zuguo; Hua, Jing; Wei, Anji; Xue, Feng; Yang, Yujing; Sun, Xinghuai; Xu, Jianjiang; 刘祖国 (LIPPINCOTT WILLIAMS & WILKINS, 2014 FEB)
      Purpose To establish normal noninvasive tear film breakup time (NI-BUT) values in the Chinese population and investigate age-related changes in NI-BUT using a newly developed Keratograph. Methods Forty normal volunteers ...