Now showing items 1075-1094 of 2317

    • Validation of a Janus role of methotrexate-based PEGylated chitosan nanoparticles in vitro 

      Luo, Fanghong; Li, Yang; Jia, Mengmeng; Cui, Fei; Wu, Hongjie; Yu, Fei; Lin, Jinya; Yang, Xiangrui; Hou, Zhenqing; Zhang, Qiqing; 罗芳洪; 侯振清; 张其清 (Luo et al.; licensee Springer., 2014)
      Recently, methotrexate (MTX) has been used to target to folate (FA) receptor-overexpressing cancer cells for targeted drug delivery. However, the systematic evaluation of MTX as a Janus-like agent has not been reported ...
    • Variations of CITED2 Are Associated with Congenital Heart Disease (CHD) in Chinese Population 

      Liu, Yan; Wang, Fengyu; Wu, Yuan; Tan, Sainan; Wen, Qiaolian; Wang, Jing; Zhu, Xiaomei; Wang, Xi; Li, Congmin; Ma, Xu; Pan, Hong; 吴媛 (PUBLIC LIBRARY SCIENCE, 2014-05-21)
      CITED2 was identified as a cardiac transcription factor which is essential to the heart development. Cited2-deficient mice showed cardiac malformations, adrenal agenesis and neural crest defects. To explore the potential ...
    • VEGF and Cortactin Expression Are Independent Predictors of Tumor Recurrence Following Curative Resection of Gastric Cancer 

      Wang, Xin; Cao, Weiguo; Mo, Mingcong; Wang, Wei; Wu, Huita; Wang, Jiejun; 王玮 (J SURG ONCOL, 2010-09-15)
      Introduction: To investigate the clinicopathological role of expression of vascular endothelial growth factor (VEGF) and cortactin, as well as whether their expression are independent predictors of tumor recurrence following ...
    • VEGF-C D2-40 E-Cad在乳腺癌中的表达及意义 

      陈毅德; 冯水土; 郑志高; 张永兴 (2009-12-15)
      目的:探讨VEGF-C、D2-40、E-Cad在乳腺癌中的表达及意义。方法:采用免疫组织化学方法,检测临床病理及随访资料完整的88例乳腺浸润性导管癌及54例导管内增生性病变组织中VEGF-C的表达情况,分析其与D2-40、E-Cad表达的关系及其临床病理意义.结果:VEGF-C在浸润癌组的阳性表达率显著性强于不典型增生组和普通型增生组;同时淋巴结转移组显著性强于无淋巴结转移组;乳腺癌变组LVD明显高于乳腺不典型增生组和普通型增生组,淋巴 ...
    • Vision-Related Quality of Life in Patients with Infectious Keratitis 

      Li, Yimin; Hong, Jiaxu; Wei, Anji; Wang, Xin; Chen, Yan; Cui, Xinhan; Sun, Xinghuai; Liu, Zuguo; Xu, Jianjiang; 刘祖国 (LIPPINCOTT WILLIAMS & WILKINS, 2014 MAR)
      Purpose To determine the vision-related quality of life (VR-QOL) in patients with infectious keratitis using the 25-item National Eye Institute Visual Function Questionnaire (NEI VFQ-25). Methods Sixty-five patients with ...
    • Voltage-Gated Potassium Channel Kv13 Is Highly Expressed in Human Osteosarcoma and Promotes Osteosarcoma Growth 

      Wu, Jin; Zhong, Daixing; Wu, Xinyu; Sha, Mo; Kang, Liangqi; Ding, Zhenqi; 吴进; 吴欣宇; 沙漠; 康两期; 丁真奇 (MDPI AG, 2013)
      Deregulation of voltage-gated potassium channel subunit Kv1.3 has been reported in many tumors. Kv1.3 promotes tumorigenesis by enhancing cell proliferation while suppressing apoptosis. However, the expression and function ...
    • Vortex Counter-Current Chromatography: Performance of a New Preparative Column 

      Ito, Yoichiro; Clary, Robert; Witten, Jacob J.; Zeng, Yun; 曾云 (CHROMATOGRAPHIA, 2012-10)
      A new preparative column for the vortex counter-current chromatograph was fabricated by making many (966) cylindrical separation units to a high-density polyethylene disk and then threading them with 6-40 taps. The resulting ...
    • WAG/Rij rats show a reduced expression of CB1 receptors in thalamic nuclei and respond to the CB1 receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges 

      van Rijn, Clementina M.; Gaetani, Silvana; Santolini, Ines; Badura, Aleksandra; Gabova, Aleksandra; Fu, Jin; Watanabe, Masashiko; Cuomo, Vincenzo; van Luijtelaar, Gilles; Nicoletti, Ferdinando; Ngomba, Richard T.; 傅瑾 (EPILEPSIA, 2010-08)
      P>Purpose: Genetically epileptic WAG/Rij rats develop spontaneous absence-like seizures after 3 months of age. We used WAG/Rij rats to examine whether absence seizures are associated with changes in the expression of type-1 ...
    • Weak link of tendon-bone healing and a control experiment to promote healing 

      Zhai, Wenliang; Lv, Chenwei; Zheng, Yanmei; Gao, Yuechuan; Ding, Zhenqi; Chen, Zhiwen; 翟文亮; 丁真奇; 陈志文 (SPRINGER, 2013)
      This study aims to observe the mechanical weak point and histological features of tendon-bone interface after anterior cruciate ligament reconstructive surgery and to explore the tendon-bone healing effects of the platelet-rich ...
    • WHAMM is required for meiotic spindle migration and asymmetric cytokinesis in mouse oocytes 

      Huang, Xin; Ding, Lu; Pan, Rui; Ma, Peng-Fei; Cheng, Pan-Pan; Zhang, Chun-Hui; Shen, Yu-Ting; Xu, Lin; Liu, Yu; He, Xiao-Qin; Qi, Zhong-Quan; Wang, Hai-Long; 许林; 齐忠权; 王海龙 (SPRINGER, 2013)
      WASP homolog associated with actin, membranes and microtubules (WHAMM) is a newly discovered nucleation-promoting factor that links actin and microtubule cytoskeleton and regulates transport from the endoplasmic reticulum ...
    • Wnt信号通路与骨关节炎的研究进展 

      丰哲; 肖茜; 练克俭 (2017)
      骨关节炎(0A)是一类多见于中老年人的以关节软骨慢性退变为主、继发关节缘骨赘和滑膜慢性炎症为特征的关节疾病。女性发病率较高。其刚开始的、主要的病理表现为退行性变,软骨最先出现局部软化、糜烂,继而外露出软骨下骨,外露的软骨下骨硬化,出现囊性变,随后继发关节周围组织关节滑液、骨膜、滑膜等渐进性病理改变,肌肉组织相应出现挛缩与松弛等变化,从而破坏关节面的应力平衡,使关节形成恶性循环改变,病变逐渐加重。其发生机理与衰老、
    • WZX中医舌色分析系统的设计与实现 

      张志枫; 王志国; 周昌乐; 许家佗; 顾超; 朱凤兰; 包含飞 (2005-06-15)
      WZX中医舌色分析系统整个程序在WinXp,VC6.0环境下编译实现。CDib类选用《VC++.Net图像处理编程》所附类库。WZX中医舌色分析系统功能包括:基本功能(显示、对比、历史记录等)、主要功能(舌体图像提取、舌象区域分割、色度测量等)。文章对WZX中医舌色分析系统功能实现中的一些技术问题进行了探讨。
    • WZX舌色分析系统在胃病患者舌像信息处理中的应用 

      张志枫; 顾超; 王志国; 许家佗; 周昌乐 (2004-09-25)
      为探讨不同证型、不同病种胃病患者的舌像特征 ,应用自主开发的WZX舌色分析系统 ,对 3 43例胃病患者的舌像进行信息处理。实验结果表明 ,肝胃不和证及脾胃湿热证患者的舌质H值向红色偏移 ,胃络瘀血证患者的舌质H值向蓝色 (紫色 )偏移 ;胃络瘀血证与脾胃虚寒证 ,胃络瘀血证与肝胃不和证 ,胃络瘀血证与脾胃湿热证患者舌质H值有显著差异 (P <0 0 5 ) ;肝胃不和证与脾胃湿热证 ,肝胃不和证与胃阴虚证 ,肝胃不和证与脾胃虚寒证患者白苔H值有显著差异 ...
    • X gene/core promoter deletion mutation: A novel mechanism leading to hepatitis B 'e' antigen-negative chronic hepatitis B 

      Zhou, Fei; Xu, Hongzhi; Chen, Meiya; Xiao, Hongmin; Zhang, Zhiping; Lu, Yapi; Ren, Jianlin; Dong, Jing; 许鸿志; 任建林 (SPANDIDOS PUBL LTD, 2014 AUG)
      Mutations in the precore and core promoter regions of hepatitis B 'e' antigen (HBeAg) are implicated in HBeAg-negative chronic hepatitis B virus (HBV) infection (CHB). The objective of the current study was to investigate ...
    • Xenoreactive CD4(+) memory T cells resist inhibition by anti-CD44 mAb and reject islet grafts via a Th2-dependent pathway 

      Peng, Yuanzheng; Chen, Jibing; Shao, Wei; Wang, Feiyu; Dai, Helong; Cheng, Panpan; Xia, Junjie; Wang, Feng; Huang, Ruxin; Zhu, Qi; Qi, Zhongquan; 王凤; 朱琪; 齐忠权 (XENOTRANSPLANTATION, 2011-JUL-A)
      Background: Memory T cells are a significant barrier to the induction of transplant tolerance. Our previous study demonstrated that multiple applications of anti-CD44 monoclonal antibody (mAb) could significantly inhibit ...
    • X连锁淋巴细胞异常增生症死亡1例 

      丘劲华; 程丛林; 张蓓蕾 (2017)
      XLP存在复杂多样的临床表现,其中以爆发性传染性单核细胞增多症型临床经过尤为凶险,诊疗过程中多无法及时诊断,且对症治疗方案多无明显效果,患者可迅; 速死亡,极易引起医疗损害而需要法医学鉴定。笔者认为遇到怀疑XLP进行鉴定时需把握下列几个要点:(1)该病发病机理为病毒感染引起淋巴细胞过度增殖,; 浸润多个器官,需做CD20、CD3、TdT、MPO等抗体的免疫组织化学染色,以鉴定增殖淋巴细胞的类型,排除其他血液系统疾病;(2)该疾病属性连锁; ...
    • Y-type partial duplication of a vaginal ectopic ureter with ipsilateral hypoplastic pelvic kidney and bicornuate uterus 

      Chen, Shushang; Zhu, Lingfeng; Yang, Shunliang; Tan, Jianming; 杨顺良; 谭建明 (SINGAPORE MEDICAL ASSOC, 2013)
      We present a case of vaginal ectopic ureter with ipsilateral partial duplication of the upper ureter (Y-type ureter), ipsilateral hypoplastic pelvic kidney and bicornuate uterus in a 20-year-old woman, who presented with ...
    • α-干扰素联合柴胡疏肝散治疗慢性乙型肝炎的临床观察及对TNF-α、IL-6的影响 

      陈少东; 张利敏; 王瑶瑶; 唐金模; 杨嘉恩; 吴春城; 王敏; 梁惠卿 (2017)
      目的:探讨柴胡疏肝散、甘草酸二铵肠溶胶囊对α-干扰素(interferon-alpha,IFN-α)治疗慢性乙型肝炎(chronic hepatitis B,CHB)疗效的观察及对肿瘤坏死因子-α(tumor necrosis factorα,TNF-α)、白细胞介素-6(interleukin-6,IL-6)水平的影响。方法:524例慢性乙型肝炎,按随机数字表法随机分为单药治疗组174例,联合中药治疗组174例,联合西药治疗组176例 ...
    • α-生育酚琥珀酸酯抗小鼠Ehrlich氏腹水癌作用的研究 

      李红卫; 吴坤 (2006-09-30)
      背景与目的研究α-生育酚琥珀酸酯(α-Tocopherylsuccinate,α-TOS)抑制实验动物体内肿瘤的生长作用,并探讨其作用机制。材料与方法建立Ehrlich氏腹水癌小鼠实验动物模型,设阴性对照组、肿瘤模型对照组、α-TOS实验组(20、40和80mg/kg)和环磷酰胺对照组,观察α-TOS对Ehrlich氏腹水癌小鼠生存期的延长作用,检测各实验组动物血液学指标、NK细胞活性、T细胞亚群,应用DNA琼脂糖凝胶电泳检测α-TOS ...
    • α-羟丁酸脱氢酶与乳酸脱氢酶比值的临床意义 

      陈振胜; 金宏伟; 黄回滨; 陈美珺 (2005-07-30)
      目的探讨α-羟丁酸脱氢酶与乳酸脱氢酶比值对心肌梗死的诊断价值。方法采用470例血清HBDH升高患者血清,分为心肌梗死组、脑部疾病组、肺部疾病组、肝脏疾病组、肾脏疾病组,测定血清中α-羟丁酸脱氢酶与乳酸脱氢酶比值。同时,设正常对照组。结果心肌梗塞组及脑部疾病组HBDH/LDH比值明显升高,与正常对照组有着显著性差异(P<0.05),其他各组与正常对照组无显著性差异(P>0.05)。结论以HBDH/LDH的比值诊断心肌梗塞较之单纯用HBDH ...