Now showing items 698-717 of 2316

    • P21-activated protein kinase 1 induces colorectal cancer metastasis involving ERK activation and phosphorylation of FAK at Ser-910 

      Li, Liang-Hui; Zheng, Min-Hua; Luo, Qi; Ye, Qing; Feng, Bo; Lu, Ai-Guo; Wang, Ming-Liang; Chen, Xue-Hua; Su, Li-Ping; Liu, Bing-Ya; 罗琪 (INT J ONCOL, 2010-10)
      Pak1 has been reported to be overexpressed in colorectal cancer, but the role of Pak1 in colorectal cancer remains unclear. In this study, Pak1 expression and activity were associated with aggressive behavior of colorectal ...
    • P21-activated protein kinase 1 is overexpressed in gastric cancer and induces cancer metastasis 

      Li, Liang-Hui; 李良辉; Luo, Qi; Zheng, Min-Hua; Pan, Chao; Wu, Guo-Yang; Lu, Yi-Zhuo; Feng, Bo; Chen, Xue-Hua; Liu, Bing-Ya (SPANDIDOS PUBL LTD, 2012-05)
      P21-activated protein kinase (Pak1), a main downstream effector of small Rho GTPases, plays an important role in the regulation of cell morphogenesis, motility, mitosis and angiogenesis. However, the role of Pak1 in gastric ...
    • P38 MAPK信号传导通路与胃癌关系的研究现状 

      谢晨曦; 任建林 (中国中西医结合学会, 2008-10-28)
      丝裂原活化蛋白激酶(mitogen-activated protein kinases,MAPKs)级联反应是细胞内重要的信号传导系统之一,参与细胞生长、发育、分化和凋亡等一系列生理、病理过程.P38MAPK信号传导通路是MAPK通路的分支之一,介导了应激、炎性细胞因子、细菌产物等多种刺激引起的细胞反应,对细胞周期调控具有重要作用.但对不同的胃癌细胞系,或者不同的刺激,P38通路的作用不完全相同,甚至可能相反.提示对P38通路的功能仍需 ...
    • p53-mediated cell cycle arrest and apoptosis induced by shikonin via a caspase-9-dependent mechanism in human malignant melanoma A375-S2 cells 

      Wu, Z.; Wu, L. J.; Li, L. H.; Tashiro, S.; Onodera, S.; Ikejima, T.; 吴振 (2004)
      Natural products regulate cell growth in response to oncogene activation that induces cell cycle arrest and apoptosis in tumor cell lines. We investigated the mechanisms of caspase activation in human malignant melanoma, ...
    • Palmitate Causes Endoplasmic Reticulum Stress and Apoptosis in Human Mesenchymal Stem Cells: Prevention by AMPK Activator 

      Lu, Jun; Wang, Qinghua; Huang, Lianghu; Dong, Huiyue; Lin, Lingjing; Lin, Na; Zheng, Feng; Tan, Jianming; 路君; 郑丰; 谭建明 (ENDOCRINOLOGY, 2012-11)
      Elevated circulating saturated fatty acids concentration is commonly associated with poorly controlled diabetes. The highly prevalent free fatty acid palmitate could induce apoptosis in various cell types, but little is ...
    • Pancreatectomy Combined with Superior Mesenteric Vein-Portal Vein Resection for Pancreatic Cancer: A Meta-analysis 

      Zhou, Yanming; Zhang, Zhiming; Liu, Yujian; Li, Bin; Xu, Donghui; 许东晖 (SPRINGER, 2012-04)
      Pancreatectomy combined with superior mesenteric vein-portal vein resection (VR) for pancreatic cancer remains a matter of debate. The present study is a meta-analysis of the available evidence. Articles published until ...
    • Pancreatic fistula after central pancreatectomy: case series and review of the literature 

      Zhou, Yan-Ming; Zhang, Xiao-Feng; Wu, Lu-Peng; Su, Xu; Li, Bin; Shi, Le-Hua; 周彦明; 李滨 (ZHEJIANG UNIV SCH MEDICINE, 2014-04-15)
      BACKGROUND: Postoperative pancreatic fistula is one of the most common complications after pancreatectomy. This study aimed to assess the occurrence and severity of pancreatic fistula after central pancreatectomy. METHODS: ...
    • Parthenolide induces apoptosis and lytic cytotoxicity in Epstein-Barr virus-positive Burkitt lymphoma 

      Li, Yuan; Zhang, Yongli; Fu, Mingming; Yao, Qin; Zhuo, Huiqin; Lu, Quanyi; Niu, Xiaoqing; Zhang, Peng; Pei, Yihua; Zhang, Kejie; 鹿全意; 牛小青; 张鹏; 张可杰 (MOL MED REP, 2012-09)
      Burkitt lymphoma (BL) has been reported to be strongly associated with Epstein-Barr virus (EBV) infection. The fact that EBV is generally present in cancer cells but rarely found in healthy cells represents an opportunity ...
    • Partial Regulatory T Cell Depletion Prior to Schistosomiasis Vaccination Does Not Enhance the Protection 

      Wang, Xuefeng; Liu, Fan; Zhou, Sha; Xu, Zhipeng; Hoellwarth, Jason; Chen, Xiaojun; He, Lei; Zhang, Rongbo; Liu, Feng; Wang, Jun; Su, Chuan; 刘凡 (PLOS ONE, 2012-07-03)
      CD4(+)CD25(+) regulatory T cells (Tregs) do not only influence self-antigen specific immune responses, but also dampen the protective effect induced by a number of vaccines. The impact of CD4(+)CD25(+) Tregs on vaccines ...
    • PCR检测原发性肝细胞癌WWOX基因表达及意义 

      陈锦萍; 王效民; 张忠英; 游攀; 李涌; 黄建炜; 吴绍峰; 傅锦波 (江苏省医学会, 2007)
      目的检测染色体普通型脆性位点FRA16D(16q23.3-q24.1)上WWOX(WW domain containing oxidoreductase)基因在原发性肝细胞癌(HCC)中的表达及意义。方法用RT-PCR、荧光定量PCR方法分别对40例原发性肝细胞癌癌组织(以下简称肝癌组织)、癌旁组织中WWOX基因的Δ6-8变异情况及其mRNA表达差异进行检测。结果WWOX mRNA在肝癌组织的表达(0.318±0.0559)显著低于癌旁 ...
    • PDA支持下糖尿病专科护理模式的临床应用 

      胡慧芳; 丁玉兰 (2017)
      目的 以PDA(个人数字助理)为平台,建立糖尿病专科护理新模式,使责任护士对患者病情及并发症能及时观察及处理,促进糖尿病专科护理发展。方法 在PDA上设置糖尿病专科疾病的评估内容、并发症处置及高危因素的评估项目,并将评估及处置内容转化为电子病历。结果 PDA糖尿病专科疾病护理模式建立后,患者健康教育满意率较前提高,由96.3%提高至99.6%;护士糖尿病专科理论知识水平较前有提高,由86.1提高至89.4分,差异均有统计学意义(P〈0. ...
    • PDCA管理法在临床实习教学中的应用 

      黄春华; 张亚强 (2005-12-15)
      该文主要研究PDCA管理法在临床实习教学中的应用。笔者通过2003年~2005年对厦门中山医院实习生采用PDCA管理法,取得了一些成效,如建立了临床实习质量指标体系,对实习教学实施规范化,使实习生的三基培训得到了进一步加强。
    • Pediatric Physeal Slide-traction Plate Fixation for Comminuted Distal Femur Fractures in Children 

      Lin, Dasheng; Lian, Kejian; Hong, Jiayuan; Ding, Zhenqi; Zhai, Wenliang; 林达生; 练克俭; 丁真奇; 翟文亮 (J PEDIATR ORTHOPED, 2012-OCT-N)
      Background: Operative stabilization without inhibiting epiphyseal growth of pediatric comminuted distal femur fractures presents specific challenges. The purpose of this study was to evaluate the clinical efficacy of ...
    • Peptide derived from Pvfp-1 as bioadhesive on bio-inert surface 

      Jiang, Zhen; Yu, Yabiao; Du, Lina; Ding, Xiyu; Xu, Hui; Sun, Yanan; Zhang, Qiqing; 张其清 (2012-02-01)
      Surface property is one important characteristic of materials, especially for ones that are bio-inert but designed for bin-medical application. In this study, we designed a series of peptides and compared their capacities ...
    • Perioperative blood transfusion adversely affects prognosis after resection of lung cancer: a systematic review and a meta-analysis 

      Luan, Haixing; Ye, Feng; Wu, Lupeng; Zhou, Yanming; Jiang, Jie; 周彦明; 姜杰 (BIOMED CENTRAL LTD, 2014-05-23)
      Background: It is speculated that blood transfusion may induce adverse consequences after cancer surgery due to immunosuppression. This study was intended to assess the impact of perioperative blood transfusion on the ...
    • Personal experience in pediatric emergency medicine training in Canada and China 

      Lin Gang-xi; Luo Yi-ming; Cheng, Adam; Yang Shu-yu; Wang Jian-she; Goldman, Ran-D; 杨叔禹 (CHINESE MED J-PEKING, 2012-10-20)
      Currently, pediatric emergency medicine (PEM) as practiced in many developed countries is different from ours in China. Chinese pediatric emergency medicine is just children's internal medicine and does not include general ...
    • Perspective from the heart: The potential of human pluripotent stem cell-derived cardiomyocytes 

      Xu, Xiu Qin; Sun, William; 徐秀琴 (WILEY-BLACKWELL, 2013)
      Human pluripotent stem cells (hPSC) are self-renewing cells with the potential to differentiate into a variety of human cells. They hold great promise for regenerative medicine and serve as useful in vitro models for ...
    • PH-DEPENDENT HYDROLYSIS AND DRUG-RELEASE OF CHITOSAN POLYETHER INTERPENETRATING POLYMER NETWORK HYDROGEL 

      Yao, K. D.; Peng, T.; Xu, M. X.; Yuan, C.; Goosen, M. F. A.; Zhang, Q. Q.; Ren, L.; 张其清 (1994)
      This paper describes a novel hydrogel based on crosslinked chitosan with glutaraldehyde interpenetrating polyether polymer network. The gel can hydrolyse in acid at 37-degrees-C due to the cleavage of imine bonds within ...
    • pH-responsive swelling behavior of collagen complex materials 

      Zhang, Q. Q.; Liu, L. R.; Zhou, H. Y.; Wu, X. Y.; Yao, K. D.; 张其清 (2000)
      This article deals with an natural collagen blended with chitosan, poly(vinyl alcohol)(PVA). We investigated the swelling properties-of collagen and collagen complex in the solution with different pH, and the swelling/deswelling ...
    • Pharmacokinetics, tissue distribution and excretion study of dl-praeruptorin A of Peucedanum praeruptorum in rats by liquid chromatography tandem mass spectrometry 

      Zhang, Z.; Liu, Y. Y.; Su, M. Q.; Liang, X. F.; Wang, W. F.; Zhu, X.; 朱铉 (PHYTOMEDICINE, 2011-04-15)
      dl-Praeruptorin A (Pd-la), isolated from Chinese traditional herbal medicine Peucedanum praeruptorum Dunn, has been proved to be a novel Ca(2+)-influx blocker and K(+)-channel opener, and displayed bright prospects in ...