Now showing items 646-665 of 2316

    • N-(2-hydroxypropyl)-3-trimethylammonium chitosan-poly(epsilon-caprolactone) copolymers and their antibacterial activity 

      Wu, Hua; Zhang, Jun; Xiao, Bo; Zan, Xiaoli; Gao, Juan; Wan, Ying; 吴华 (CARBOHYD POLYM, 2011-01-10)
      Chitosan-poly(epsilon-caprolactone) (CPC) copolymers were synthesized via an amino-group-protection method Selected CPCs with poly(epsilon-caprolactone) content less than 50 wt% were further modified by introducing quaternary ...
    • N-(2-羟基乙基)芥酰胺对高脂血症金黄地鼠的降脂及保肝作用 

      沈燕慧; 金鑫; 赵云; 古丽米然·阿里同别克; 林丽敏; 舒萍; 魏晓 (2012-09-12)
      <正>高脂血症是诱发心血管疾病的主要危险因素之一,控制血脂的升高对于预防心血管疾病具有十分重要的意义。对于多数患者来说,单纯通过改善饮食结构来严格控制血脂水平是比较困难的,通常需要借助药物进行治疗。目前临床上广泛使用的降血脂药物主要包括HMG-COA还原酶抑制剂、贝特类等。研究表明,过氧化物酶体增殖激活受体α(PPARα)激动剂具有调血脂功能,其合成配体贝特类已成为治疗高脂血症的一线药物,但长期应用易引起肝脏
    • National survey of the medical treatment status for non-small cell lung cancer (NSCLC) in China 

      Xue, Cong; Hu, Zhihuang; Jiang, Wei; Zhao, Yuanyuan; Xu, Fei; Huang, Yan; Zhao, Hongyun; Wu, Jingxun; 吴敬勋; Zhang, Yang; Zhao, Liping; Zhang, Jing; Chen, Likun; Zhang, Li (ELSEVIER IRELAND LTD, 2012-08)
      Introduction: Treatment choice for NSCLC in China has not previously been reported. This paper explores the clinical practice and adherence to treatment guidelines for NSCLC. Methods: A specifically designed questionnaire ...
    • Na~+/Ca2~(+)交换对狗心室肌细胞复极的影响 

      巩燕; 王焱; Bela Szabo (2005-10-25)
      探讨生理状态下Na+/Ca2+交换(NCX)双向模式的离子转换对复极的影响,以及在转换失调时是否为潜在的触发心律失常的机制。应用全细胞膜片钳技术研究单个心室肌细胞在不同频率刺激下动作电位时程(APD)的变化、药物干预改变NCX活性的条件下APD的变化以及与细胞舒张的关系。结果:固定频率(1.0Hz)刺激APD的变化范围和频率改变(0.6~1.0Hz)时APD的变化范围均在一个相对固定的膜电位(10~40mV)范围内。用10mmol/LE ...
    • Near-IR sensitive Au-Au2S nanoparticles with biocompatibility for drug delivery 

      Liu, Wen; Wang, Zu-yong; Yin, Pei; Ren, Lei; Zhang, Qi-qing; Lau, AKT; Lu, J; Varadan, VK; Chang, FK; Tu, JP; Lam, PM; 张其清 (2008)
      The near-infrared (NIR) sensitive Au-Au2S nanoparticles (NPs) have shown many advantages as potential drug delivery systems. To further investigate biological safety of Au-Au2S NPs, cytotoxicity was estimated by calcein ...
    • Netrin-1 Simultaneously Suppresses Corneal Inflammation and Neovascularization 

      Han, Yun; Shao, Yi; Lin, Zhirong; Qu, Yang-Luowa; Wang, He; Zhou, Yueping; Chen, Wensheng; Chen, Yongxiong; Chen, Wei-Li; Hu, Fung-Rong; Li, Wei; Liu, Zuguo; 李炜; 刘祖国 (INVEST OPHTH VIS SCI, 2012-03)
      PURPOSE. To investigate the effect of netrin-1 on alkali burn-induced corneal inflammation and neovascularization. METHODS. The expression of netrin-1 and its receptors UNC5A, UNC5B, UNC5C, UNC5D, adenosine 2b receptor ...
    • Neuron-Specific Menin Deletion Leads to Synaptic Dysfunction and Cognitive Impairment by Modulating p35 Expression 

      Kai Zhuang; 庄恺; Changquan Huang; Lige Leng; Honghua Zheng; Yuehong Gao; Guimiao Chen; Zhilin Ji; Hao Sun; Yu Hu; Di Wu; Meng Shi; Huifang Li; Yingjun Zhao; Yunwu Zhang; 张云武; Maoqiang Xue; Guojun Bu; 卜国军; Timothy Y. Huang; Huaxi Xu; 许华曦; Jie Zhang; 张杰 (Elsevier Inc., 2018-07-17)
      【Abstract】Menin (MEN1) is a critical modulator of tissue development and maintenance. As such, MEN1 mutations are associated with multiple endocrine neoplasia type 1 (MEN1) syndrome. Although menin is abundantly expressed ...
    • Neuronal Clearance of Amyloid-beta by Endocytic Receptor LRP1 

      Kanekiyo, Takahisa; Cirrito, John R.; Liu, Chia-Chen; Shinohara, Mitsuru; Li, Jie; Schuler, Dorothy R.; Shinohara, Motoko; Holtzman, David M.; Bu, Guojun; 卜国军 (SOC NEUROSCIENCE, 2013-Dec 4)
      Alzheimer's disease (AD) is the most prevalent form of dementia in the elderly population. Accumulation, aggregation, and deposition of amyloid-beta (A beta) peptides generated through proteolytic cleavage of amyloid ...
    • Neuropsychiatric disorders secondary to neurosyphilis in elderly people: one theme not to be ignored 

      Zeng, Yan-Li; Wang, Wen-Jie; Zhang, Hui-Lin; Chen, Fu-Yi; Huang, Song-Jie; Liu, Gui-Li; Xi, Ya; Guo, Xiao-Jing; Zheng, Wei-Hong; Yang, Tian-Ci; 郑维红; 杨天赐 (CAMBRIDGE UNIV PRESS, 2013)
      Background: Neurosyphilis (NS) may present with neuropsychiatric disorders characterized by cognitive impairment, personality disorders, and confusion, among others. Very few studies have focused on neuropsychiatric disorders ...
    • New A-nor steroids and their antifouling activity from the Chinese marine sponge Acanthella cavernosa 

      Qiu, Yan; Deng, Zhi Wei; Xu, Minjuan; Li, Qingshan; Lin, Wen Han; 邱彦 (STEROIDS, 2008-12-22)
      A chemical examination of the Chinese sponge Acanthella cavernosa resulted in the isolation of three new A-ring contracted steroids, the ethyl esters of 2 beta-hydroxy-4,7-diketoA-norcholest-5-en-2-oic acid (1), 24S-ethyl-2 ...
    • New Method to Prepare Mitomycin C Loaded PLA-Nanoparticles with High Drug Entrapment Efficiency 

      Hou, Z. Q.; Wei, H.; Wang, Q.; Sun, Q.; Zhou, C. X.; Zhan, C. M.; Tang, X. L.; Zhang, Q. Q.; 张其清 (2009-07)
      The classical utilized double emulsion solvent diffusion technique for encapsulating water soluble Mitomycin C (MMC) in PLA nanoparticles suffers from low encapsulation efficiency because of the drug rapid partitioning to ...
    • Nicotine exerts neuroprotective effects against beta-amyloid-induced neurotoxicity in SH-SY5Y cells through the Erk1/2-p38-JNK-dependent signaling pathway 

      Xue, Mao Qiang; Liu, Xiao Xing; Zhang, Yan Ling; Gao, Feng Guang; 薛茂强; 高丰光 (SPANDIDOS PUBL LTD, 2014 APR)
      Epidemiological data have indicated that smoking tobacco can decrease the risk of developing Alzheimer's disease (AD). Nicotine, a main component of tobacco, has been shown to have therapeutic effects in AD. The aim of the ...
    • Nicotine promotes cell proliferation and induces resistance to cisplatin by a7 nicotinic acetylcholine receptor-mediated activation in Raw2647 and El4 cells 

      Wang, Yan Yan; Liu, Yao; Ni, Xiao Yan; Bai, Zhen Huan; Chen, Qiong Yun; Zhang, Ye; Gao, Feng Guang; 张业; 高丰光 (SPANDIDOS PUBL LTD, 2014 MAR)
      Although nicotine is a risk factor for carcinogenesis and atherosclerosis, epidemiological data indicate that nicotine has therapeutic benefits in treating Alzheimer's disease. Our previous studies also showed that ...
    • Nicotine stimulated bone marrow-derived dendritic cells could augment HBV specific CTL priming by activating PI3K-Akt pathway 

      Jin, Hao Jie; Li, Hai Tao; Sui, Hua Xiu; Xue, Mao Qiang; Wang, Yi Nan; Wang, Jia Xun; Gao, Feng Guang; 高丰光 (ELSEVIER SCIENCE BV, 2012-08-30)
      Our previous studies have revealed that nicotine-treated immature dendritic cells (imDCs) have antitumor effects in murine lymphoma models. The present study is to explore HBV-specific CTL priming and its cytolytic activities ...
    • Nicotine Stimulated Dendritic Cells Could Achieve Anti-Tumor Effects in Mouse Lung and Liver Cancer 

      Gao, Feng Guang; Li, Hai Tao; Li, Zhi Jing; Gu, Jian Ren; 高丰光 (J CLIN IMMUNOL, 2011-01)
      Our previous studies have revealed that nicotine-treated immature dendritic cells (imDCs) have anti-tumor effects in murine lymphoma models. The present study is to explore the preventive and therapeutic anti-tumor effects ...
    • Nicotine Up-regulated 4-1BBL Expression by Activating Mek-PI3K Pathway Augments the Efficacy of Bone Marrow-Derived Dendritic Cell Vaccination 

      Jin, Hao Jie; Sui, Hua Xiu; Wang, Yi Nan; Gao, Feng Guang; 高丰光 (SPRINGER/PLENUM PUBLISHERS, 2013)
      Purpose To explore the role of 4-1BBL in nicotine-treated immature dendritic cells (imDCs) mediated anti-tumor effects. Methods Bone marrow-derived imDCs were stimulated with nicotine and 4-1BBL expression was determinated ...
    • Non-spherical racemic polylactide microarchitectures formation via solvent evaporation method 

      Zhou, Z. M.; Xu, J.; Liu, X. Q.; Li, X. M.; Li, S. Y.; Yang, K.; Wang, X. F.; Liu, M.; Zhang, Q. Q.; 张其清 (2009-07-17)
      Usually, amphiphilic or crystalline structure is necessary to prepare nano- or micro-structured materials with various morphologies. Racemic random polylactide (PDLLA) is completely amorphous in nature and was mainly ...
    • Noscapine sensitizes chemoresistant ovarian cancer cells to cisplatin through inhibition of HIF-1 alpha 

      方亚 (2011)
      Hypoxia-inducible factor 1 alpha (HIF-1 alpha) is closely related with chemoresistance of solid tumors. The purpose of this study was to investigate the ability of noscapine to inhibit HIF-1 alpha and sensitize ovarian ...
    • Notch Signal Regulates Corneal Endothelial-to-Mesenchymal Transition 

      Li, Cheng; Dong, Fei; Jia, Yanni; Du, Huiyi; Dong, Nuo; Xu, Yajie; Wang, Shen; Wu, Huping; Liu, Zuguo; Li, Wei; 李程; 董诺; 吴护平; 刘祖国; 李炜 (ELSEVIER SCIENCE INC, 2013)
      Endothelial-to-mesenchymal transition (EnMT) is a cell transformation process involved in both morphogenesis and pathogenesis. EnMT of corneal endothelial cells happens after endothelial injury and during ex vivo culture. ...
    • Notch-1 signaling facilitates survivin expression in human non-small cell lung cancer cells 

      Chen, Yuqing; Li, Dianming; Liu, Hongli; Xu, Huanbai; Zheng, Honghua; Qian, Feng; Li, Wei; Zhao, Chengling; Wang, Zhenhuan; Wang, Xiaojing; 郑红花 (CANCER BIOL THER, 2011-01-01)
      The oncogenic potential of Notch activation is observed in many instances including lung tumorigenesis, but the associated molecular regulatory mechanism has not been thoroughly defined. It has been demonstrated that hypoxia ...