Now showing items 572-591 of 2317

    • M1 muscarinic acetylcholine receptor in Alzheimer's disease 

      Jiang, Shangtong; Li, Yanfang; Zhang, Cuilin; Zhao, Yingjun; Bu, Guojun; Xu, Huaxi; Zhang, Yun-Wu; 李艳芳; 卜国军; 许华曦; 张云武 (SPRINGER, 2014 APR)
      The degeneration of cholinergic neurons and cholinergic hypofunction are pathologies associated with Alzheimer's disease (AD). Muscarinic acetylcholine receptors (mAChRs) mediate acetylcholine-induced neurotransmission and ...
    • Magnetic resonance imaging: a valuable method for diagnosing chronic lumbago caused by lumbar muscle strain and monitoring healing process 

      Ouyang Lin; Jia Qian-xin; Xiao Yu-hui; Ke Lai-shun; He Ping; 郏潜新; 柯来顺; 何平 (CHINESE MEDICAL ASSOC, 2013-Jul 5)
      Background Magnetic resonance imaging (MRI) is the most sensitive technique for evaluating the healing process and should be performed before the patients return to their exercise routines. The aim of this research was to ...
    • Magnetite nanoparticles as smart carriers to manipulate the cytotoxicity of anticancer drugs: Magnetic control and pH-responsive release 

      Zhao, Zhenghuan; Huang, Dengtong; Yin, Zhenyu; Chi, Xiaoqin; Wang, Xiaomin; Gao, Jinhao; 尹震宇; 池小琴; 王效民; 高锦豪 (Royal Society of Chemistry, 2012 Augus)
      We described the smart and targeted magnetic nanocarriers to control the delivery and release of anticancer drug doxorubicin (DOX) in vitro and demonstrated that they can exhibit much higher cytotoxicity to cancer cells ...
    • Manage orbital apex lesions via posterior lateral orbitotomy 

      Wu Xi-yue; Zheng Shu-fa; Jiang Chang-zhen; Wang Chen-yang; Kang De-zhi; Fu Jin; 傅瑾 (CHINESE MED J-PEKING, 2012-10-05)
    • Matrine induces caspase-independent program cell death in hepatocellular carcinoma through bid-mediated nuclear translocation of apoptosis inducing factor 

      Zhou, Huan; Xu, Minying; Gao, Ya; Deng, Zhigang; Cao, Hanwei; Zhang, Wenqing; Wang, Qiao; Zhang, Bing; Song, Gang; Zhan, Yanyan; Hu, Tianhui; 邓志刚; 张兵; 宋刚; 占艳艳; 胡天惠 (BIOMED CENTRAL LTD, 2014-03-16)
      Matrine, a clinical drug in China, has been used to treat viral hepatitis, cardiac arrhythmia and skin inflammations. Matrine also exhibits chemotherapeutic potential through its ability to trigger cancer cell death. ...
    • McAb_3D_3与平阳霉素交联物的制备及其细胞杀伤实验 

      苏金华; 颜江华; 林炳珍; 郑耘; 杨善民 (1996)
      用dEXTrAnT40为中介体的方法交联抗人肺腺癌单抗3d3和平阳霉素(A5),每克分子抗体可携带68克分子的药物,交联物中抗体活性仍能达到10-4水平,能较好地与靶细胞l-342结合。体外细胞毒实验,显示交联物和游离A5对靶细胞50%杀伤浓度分别为0.9μMOl/l和4.6μMOl/l,杀伤效果比游离A5强5倍多。单抗对靶细胞几乎没有杀伤作用;无关抗体交联物的作用也很弱。交联物和游离A5对非靶细胞MgC-803的杀伤作用无明显差别。结 ...
    • MCM7 expression predicts post-operative prognosis for hepatocellular carcinoma 

      Zhou, Yan-Ming; Zhang, Xiao-Feng; Cao, Lu; Li, Bin; Sui, Cheng-Jun; Li, Yu-Min; Yin, Zheng-Feng; 李滨 (LIVER INT, 2012-11)
      Background Dysregulation of minichromosome maintenance protein 7 (MCM7) was previously identified in multiple human malignancies. The clinical significance of MCM7 expression is yet to be delineated in patients with ...
    • MDR1基因多态性与肝癌易感性的关系 

      陈毅德; 杨芳; 冯水土; 张永兴 (2009-12-15)
      目的:探讨MDR1基因位点单核苷酸多态性与肝癌易感性的关系。方法:采用病例对照研究,应用聚合酶链反应限制性片段长度多态性(PCR-RFLP)基因型分析技术测定原发性肝癌组及正常健康对照组各100例MDR1基因G2677T/A位点。以χ2检验比较MDR1多态基因型及相关危险在病例与对照之间分布的差异,采用非条件Logistic回归分析多态基因型与肝癌发生危险度的关系。结果:肝癌组MDR1基因2677A携带型低于健康对照组(P<0.05); ...
    • Mediator MED23 regulates basal transcription in vivo via an interaction with P-TEFb 

      Wang, Wei; Yao, Xiao; Huang, Yan; Hu, Xiangming; Liu, Runzhong; Hou, Dongming; Chen, Ruichuan; Wang, Gang; 陈瑞川 (2013-01-01)
      The Mediator is a multi-subunit complex that transduces regulatory information from transcription regulators to the RNA polymerase II apparatus. Growing evidence suggests that Mediator plays roles in multiple stages of ...
    • Mediator MED23 regulates basal transcription in vivo via an interaction with P-TEFb 

      Wang, Wei; Yao, Xiao; Huang, Yan; Hu, Xiangming; Liu, Runzhong; Hou, Dongming; Chen, Ruichuan; Wang, Gang; 陈瑞川 (2013-01-01)
      The Mediator is a multi-subunit complex that transduces regulatory information from transcription regulators to the RNA polymerase II apparatus. Growing evidence suggests that Mediator plays roles in multiple stages of ...
    • MEK inhibition reduces glial scar formation and promotes the recovery of sensorimotor function in rats following spinal cord injury 

      Lin, Bin; Xu, Yang; Zhang, Bi; He, Yong; Yan, Yun; He, Ming-Chang; 林斌; 徐洋 (SPANDIDOS PUBL LTD, 2014 JAN)
      The aim of this study was to investigate the effect of U0126 on the formation of glial scars following spinal cord injury (SCI) in a rat model. Ninety adult female Sprague-Dawley rats were divided randomly into sham injury ...
    • MEN1基因生物学功能研究进展 

      金光辉; 曾德泉; 徐斌 (2011-03-28)
      MEN1基因是多发性内分泌肿瘤1型综合征(MEN1)的关键致病基因之一.其编码蛋白menin在细胞核中与混合谱系淋巴瘤基因(MLL)等大量关键转录因子相互作用,直接参与组蛋白甲基化修饰等表观遗传调控过程,对靶基因转录和细胞表型的维持起关键的调控作用.MEN1基因突变导致的menin表达或核转位异常将引起一系列信号通路紊乱,进而引起内分泌系统疾病如MEN1.近年来,随着研究的深入,发现menin参与调控的组蛋白3的赖氨酸4残基(H3K4) ...
    • MEN1胰岛瘤中细胞周期蛋白cyclin B2高表达的作用和机制 

      吴婷; 黄小花 (2011-12-25)
      多发性内分泌肿瘤1型(multiple endocrine neoplasia type1,MEN1)是一种常染色体显性遗传的肿瘤综合征,患者常表现出多发性的内分泌器官肿瘤,包括垂体瘤、甲状旁腺瘤和胰岛瘤。抑癌基因Men1的突变导致MEN1的发生,其编码的蛋白为核蛋白menin。Menin可以抑制包括胰岛β细胞在内的内分泌细胞增殖。本文探讨menin通过抑制细胞增殖来抑制MEN1胰岛瘤的可能机制。在基因芯片的分析中,喂养它莫西酚(tam ...
    • MEN1胰岛瘤中细胞周期蛋白cyclinB2高表达的作用和机制 

      吴婷; 黄小花 (2011)
      多发性内分泌肿瘤1型(MulTIPlE EndOCrInE nEOPlASIA TyPE1,MEn1)是一种常染色体显性遗传的肿瘤综合征,患者常表现出多发性的内分泌器官肿瘤,包括垂体瘤、甲状旁腺瘤和胰岛瘤。抑癌基因MEn1的突变导致MEn1的发生,其编码的蛋白为核蛋白MEnIn。MEnIn可以抑制包括胰岛β细胞在内的内分泌细胞增殖。本文探讨MEnIn通过抑制细胞增殖来抑制MEn1胰岛瘤的可能机制。在基因芯片的分析中,喂养它莫西酚(TAM ...
    • Menin Deficiency Leads to Depressive-like Behaviors in Mice by Modulating Astrocyte-Mediated Neuroinflammation 

      Lige Leng; 冷历歌; Kai Zhuang; 庄恺; Zeyue Liu; 刘泽玥; Changquan Huang; Yuehong Gao; Guimiao Chen; Hui Lin; Yu Hu; Di Wu; Meng Shi; Wenting Xie; Hao Sun; Zhicheng Shao; Huifang Li; Kunkun Zhang; Wei Mo; 莫玮; Timothy Y. Huang; Maoqiang Xue; 薛茂强; Zengqiang Yuan; 袁增强; Xia Zhang; 张遐; Guojun Bu; 卜国军; Huaxi Xu; 许华曦; Qi Xu; Jie Zhang; 张杰 (Elsevier Inc., 2018-09-13)
      【Abstract】Astrocyte dysfunction and inflammation are associated with the pathogenesis of major depressive disorder (MDD). However, the mechanisms underlying these effects remain largely unknown. Here, we found that multiple ...
    • Menin Directly Represses Gli1 Expression Independent of Canonical Hedgehog Signaling 

      Gurung, Buddha; Feng, Zijie; Hua, Xianxin; 冯子杰 (AMER ASSOC CANCER RESEARCH, 2013)
      Multiple endocrine neoplasia type 1 (MEN-1), is a familial tumor syndrome resulting from mutations in the tumor suppressor gene menin (MEN1). Menin plays an essential role in both repressing and activating gene expression. ...
    • Menin Epigenetically Represses Hedgehog Signaling in MEN1 Tumor Syndrome 

      Gurung, Buddha; Feng, Zijie; Iwamoto, Daniel V.; Thiel, Austin; Jin, Guanghui; Fan, Chen-Min; Ng, Jessica M. Y.; Curran, Tom; Hua, Xianxin; 金光辉 (AMER ASSOC CANCER RESEARCH, 2013-Apr 1)
      Multiple endocrine neoplasia type 1 (MEN1) is an inherited tumor syndrome that includes susceptibility to pancreatic islet tumors. This syndrome results from mutations in the MEN1 gene, encoding menin. Although menin acts ...
    • Menin expression is regulated by transforming growth factor beta signaling in leukemia cells 

      Zhang Hui; Liu Zu-guo; Hua Xian-xin; 刘祖国 (CHINESE MED J-PEKING, 2011-05-20)
      Background Menin is a ubiquitously expressed protein encoded by the multiple endocrine neoplasia type 1 (MEN1) gene. Besides its importance in endocrine organs, menin has been shown to interact with the mixed lineage ...
    • Menin promotes hepatocellular carcinogenesis and epigenetically up-regulates Yap1 transcription 

      Xu, Bin; Li, Shan-Hua; Zheng, Rong; Gao, Shu-Bin; Ding, Li-Hong; Yin, Zhen-Yu; Lin, Xiao; Feng, Zi-Jie; Zhang, Sheng; Wang, Xiao-Min; Jin, Guang-Hui; 徐斌; 李善花; 郑荣; 丁丽红; 尹震宇; 冯子杰; 金光辉 (NATL ACAD SCIENCES, 2013-Oct 2)
      Menin is a scaffold protein encoded by the multiple endocrine neoplasia type 1 (MEN1) gene in humans, and it interacts with a variety of transcriptional proteins to control active or repressive cellular processes. Here, ...
    • Menin regulates endocrine diseases by controlling histone modification and gene transcription 

      Gao, S. B.; Hua, X.; Jin, G. H.; 金光辉 (ANN ENDOCRINOL-PARIS, 2008-09)
      Multiple endocrine neoplasia type 1 (MEN1), a human familial tumor syndrome, results from mutations in the Men1 gene. Although Much progress has been made in demonstrating the definitive role for menin in Suppressing ...