Now showing items 442-461 of 2316

    • Halomonas aidingensis sp nov, a moderately halophilic bacterium isolated from Aiding salt lake in Xinjiang, China 

      Liu, Wen-Yan; Wang, Juan; Yuan, Meng; 王娟 (ANTON LEEUW INT J G, 2011-03)
      Two Gram-negative moderately halophilic bacterial strains, designated Ad-1(T) and C-12, were isolated from Aiding salt lake of Xinjiang in China. The novel isolates were subjected to a polyphasic taxonomic study. Cells of ...
    • Hamstring腱在体内重塑与转归的组织学研究 

      夏春; 张兵; 周江南; 胡海; 陈国能; 付日斌 (2006-11-01)
      目的探讨游离Hamstring腱作为替代腱重建前十字韧带(anteriorcruciateligament,ACL)后在体内的重塑与转归过程,初步确定其术后在体内成熟的时间。方法33例关节镜下自体同侧游离4~5股Hamstring腱重建ACL的患者在行关节镜下再视手术时,于移植腱体中下段取活检组织进行组织学观察。重建术至再视手术的平均时间为11.9个月。替代腱依据重建术至再视手术的时段分为1月~、4月~、7月~、10月~、13月~、18 ...
    • Hartree-Fock and density functional theory study of remote substituent effects on gas-phase heterolytic Fe-O and Fe-S bond energies of p-G-C 6H4OFe(CO)2(η5-C 5H5) and p-G-C6H4SFe(CO) 2(η5-C5H5) 

      Zeng, Qi; Li, Zucheng; Han, Daxiong; Dong, Ling; Zhai, Huaqiang; Liu, Bin; Bai, Genben; Zhang, Yujie; 韩大雄 (WILEY-BLACKWELL, 2014 Febru)
      The knowledge of accurate bond strengths is a fundamental basis for a proper analysis of chemical reaction mechanisms. Quantum chemical calculations at different levels of theory have been used to investigate heterolytic ...
    • Hartree-Fock and density functional theory study of remote substituent effects on gas-phase heterolytic Fe-O and Fe-S bond energies of p-G-C6H4OFe(CO)(2)(eta(5)-C5H5) and p-G-C6H4SFe(CO)(2)(eta(5)-C5H5) 

      Zeng, Qing; Li, Zucheng; Han, Daxiong; Dong, Ling; Zhai, Huaqiang; Liu, Bin; Bai, Genben; Zhang, Yujie; 韩大雄 (WILEY-BLACKWELL, 2014 FEB)
      The knowledge of accurate bond strengths is a fundamental basis for a proper analysis of chemical reaction mechanisms. Quantum chemical calculations at different levels of theory have been used to investigate heterolytic ...
    • HBeAg特异免疫复合物检测及临床意义 

      任建林; 张树林; 朱江; 刘宇卉 (1999-06-15)
      采用单克隆抗-HBe固相ELISA法检测118例HBV感染者血清中HBeAg特异免疫复合物(HBeAg/IC),结果表明∶HBeAg/IC与HBV复制相关,可作为HBV复制的一种血清学标志,HBeAg阴性、HBVDNA阳性者中,62.2%患者HBeAg/IC阳性,提示HBeAg/IC的形成致使夹心法不能检出HBeAg,这类患者仍可以是HBV野毒株感染,并非均为HBeAg缺陷变异株感染;HBeAg/IC阳性血清ALT异常率明显高于HBeA ...
    • HBsAg Inhibits the Translocation of JTB into Mitochondria in HepG2 Cells and Potentially Plays a Role in HCC Progression 

      Liu, Yun-Peng; Yang, Xiao-Ning; Jazag, Amarsanaa; Pan, Jin-Shui; Hu, Tian-Hui; 胡天惠; Liu, Jing-Jing; Guleng, Bayasi; Ren, Jian-Lin; 任建林 (PUBLIC LIBRARY SCIENCE, 2012-05-15)
      Background and Aims: The expression of the jumping translocation breakpoint (JTB) gene is upregulated in malignant liver tissues; however, JTB is associated with unbalanced translocations in many other types of cancer that ...
    • HBV整合的致癌性研究 

      高丰光; 王迎伟; 孙汶生; 曾令宇; 王玉龙; 周峰 (中华微生物学和免疫学杂志, 2004)
      HBV的4个亚基因产物中,HBx具有反式激活、介导细胞凋亡作用,HBs具有反式激活因子的作用。肝细胞癌(HCC)的发生与HBV的整合及整合后染色体重排有关。为探讨HBV整合及HBx、HBs亚基因在HCC发生中的可能作用,我们制备了HBV亚基因探针,并以此对肝细胞癌中HBV整合及亚基因转录进行了研究,以期为阐明HBV感染后HCC发生机制提供一定的实验资料和依据。本研究中,首先以BamHⅠ、BglⅡ酶切扩增回收的HBVDNA ...
    • HCV NS4B表达载体的构建及其对细胞凋亡的影响 

      宋彬妤; 赵嘉伟; 宋静; 陈思思; 胡志廷; 韩昕; 王敏敏; 任来峰 (2017)
      目的 构建丙型肝炎病毒(HCV)2a型非结构蛋白4B(NS4B)的真核表达载体,并观察其对骨肉瘤细胞U2OS凋亡的影响。方法 以质粒PJFH1为模板,通过PCR反应扩增4目的基因片段,采用同源重组法与PCMV-tag2b载体相连,转化大肠杆菌感受态DH5α,筛选正确的克隆。以脂质体为介导转染U2OS细胞,通过Western blot检测NS4B蛋白的表达,免疫荧光检测细胞的凋亡。结果 构建pCMV-tag2b-NS4B重组质粒,经测序其 ...
    • Hematopoietic chimerism in liver transplantation patients and hematopoietic stem/progenitor cells in adult human liver 

      Wang, Xiao Qi; Lo, Chung Mau; Chen, Lin; Cheung, Cindy K. Y.; Yang, Zhen Fan; Chen, Yong Xiong; Ng, Michael N.; Yu, Wan Ching; Ming, Xiaoyan; Zhang, Wu; Ho, David W. Y.; Chan, See Ching; Fan, Sheung Tat; 陈永雄 (HEPATOLOGY, 2012-10)
      Liver transplantation (LT) is a cure for many liver diseases. Blood chimerism of donor origin can develop after LT, which raises the possibility of the existence of hematopoietic stem/progenitor cells (HSPCs) in the liver. ...
    • Heme oxygenase induction confers cellular adaptive response against multi-walled carbon nanotubes-induced cytotoxicity in A549 cell 

      Zhong, Liming; Ye, Shefang; Wu, Yihui; Zhang, Qiqing; 张其清; Peng, Y; Zhang, Y (2008)
      Carbon nanotubes currently attract intense attention for various biomedical applications due to their large surface areas, high electrical conductivity, and excellent strength. However, these attractive properties of ...
    • Heparan Sulphate Proteoglycan and the Low-Density Lipoprotein Receptor-Related Protein 1 Constitute Major Pathways for Neuronal Amyloid-beta Uptake 

      Kanekiyo, Takahisa; Zhang, Juan; Liu, Qiang; Liu, Chia-Chen; Zhang, Lijuan; Bu, Guojun; 卜国军 (J NEUROSCI, 2011-02-02)
      Alzheimer's disease (AD) is a progressive and irreversible neurodegenerative disorder in which the aggregation and deposition of amyloid-beta (A beta) peptides in the brain are central to its pathogenesis. In healthy brains, ...
    • Hepatectomy in Elderly Patients: Does Age Matter? 

      Zhou, Yanming; Zhang, Xiaofeng; Zhang, Zuobing; Liu, Xiaobin; Wu, Lupeng; Li, Yumin; Li, Bin; 周彦明; 李滨 (SPRINGER, 2013)
      With the increase in average life expectancy in recent decades, the proportion of elderly patients requiring liver surgery is rising. The aim of the meta-analysis reported here was to evaluate the safety and efficacy of ...
    • Hepatic regeneration and the epithelial to mesenchymal transition 

      Xue, Zeng-Fu; Wu, Xiu-Min; Liu, Ming; 刘明 (BAISHIDENG PUBL GRP CO LTD, 2013-Mar 7)
      Liver injuries are repaired by fibrosis and regeneration. The core stage is the repair response and fibrosis formation as a scar. The cause of overly-responsive scar formation and diminished regeneration, especially in ...
    • Hepatic stellate cells promote tumor progression by enhancement of immunosuppressive cells in an orthotopic liver tumor mouse model 

      Zhao, Wenxiu; Zhang, Lei; Xu, Yaping; Zhang, Zhengqi; Ren, Guangli; Tang, Kai; Kuang, Penghao; Zhao, Bixing; Yin, Zhenyu; Wang, Xiaomin; 尹震宇; 王效民 (NATURE PUBLISHING GROUP, 2014 FEB)
      The immunosuppressive properties of hepatic stellate cells (HSCs) contribute to the occurrence and development of hepatocellular carcinoma (HCC). The accumulation of cells with immune suppressive activities, such as ...
    • Heterocycle-linked Phenylbenzyl Amides as Novel TRPV1 Antagonists and Their TRPV1 Binding Modes: Constraint-Induced Enhancement of In Vitro and In Vivo Activities 

      Kim, Nam-Jung; Li, Fu-Nan; Lee, Jin Hee; Park, Seul-gi; Kim, Kyeojin; Lim, Changjin; Han, Young Taek; Yun, Hwayoung; Jung, Jong-Wha; Park, Hyeung-geun; Kim, Hee-Doo; Woo, Byoung Young; Shin, Song Seok; Kim, Sun-Young; Choi, Jin Kyu; Jeong, Yeon-Su; Pa; 李福男 (WILEY-V C H VERLAG GMBH, 2013)
      A series of heterocycle-linked constrained phenylbenzyl amides were found to be TRPV1 antagonists with promising in vivo profiles. In particular, one of the analogues containing a furan linker exhibited excellent TRPV1 ...
    • Hierarchical lane-oriented 3D road-network model 

      Zhu, Q.; Li, Y.; 朱琪 (INT J GEOGR INF SCI, 2008)
      The existing road-network models based on the 2D link-node of roadway centrelines have inhibited lane-oriented network flow analysis and multi-dimensional inventory management in complicated 3D urban environments. This ...
    • High- vs Low-power Holmium Laser Lithotripsy: A Prospective, Randomized Study in Patients Undergoing Multitract Minipercutaneous Nephrolithotomy 

      Chen, Shushang; Zhu, Lingfeng; Yang, Shunliang; Wu, Weizhen; Liao, Lianming; Tan, Jianming; 杨顺良; 吴卫真; 谭建明 (UROLOGY, 2012-02)
      OBJECTIVE To determine the efficacy and safety of high-power holmium: yttrium aluminum-garnet (Ho: YAG) laser lithotripsy for multitract modified minimally invasive percutaneous nephrolithotomy (MPCNL) in the treatment of ...
    • High-Yield Fabrication of PLGA Non-Spherical Microarchitectures by Emulsion-Solvent Evaporation Method 

      Li, Ruifeng; Li, Xuemin; Liu, Lingrong; Zhou, Zhimin; Tang, Hongbo; Zhang, Qiqing; 张其清 (WILEY-V C H VERLAG GMBH, 2010-11)
      Recently, it has been recognized the shape of particles plays an essential role in the design of materials with unique properties. In this study, PLGA non-spherical microarchitectures, rods and fibers, were fabricated ...
    • Higher prevalence of human herpesvirus 8 DNA sequence and specific IgG antibodies in patients with pemphigus in China 

      Wang, GQ; Xu, HH; Wang, YK; Gao, XH; Zhao, YM; He, CD; Inoue, N; Chen, HD; 王官清 (J AM ACAD DERMATOL, 2005-03)
      Background: Environmental factors, including virus infection, may play a role in the onset and/or development of pemphigus. However, it is controversial whether human herpesvirus (HHV)-8 is involved in pathogenesis of ...
    • HJJB复方对非酒精性脂肪性肝炎大鼠胰岛素信号转导环节的影响 

      李红山; 应豪; 胡爱荣; 胡耀仁; 陈少东 (2017)
      目的观察红景天苷、姜黄素、绞股蓝总苷、白术多糖(HJJB)复方对非酒精性脂肪性肝炎(NASH)大鼠胰岛素信号转导环节的干预作用。方法采用高脂饮食; 14周诱导的大鼠胰岛素抵抗NASH模型。在造模第9周起,随机分为模型组、西药组(罗格列酮,0.4; mg/kg)和中药组(HJJB)。干预6周后,观察肝组织病理变化(HE染色),检测肝组织TG含量、ALT活性、血清空腹胰岛素(FINS)含量、空; 腹血糖(FBG)含量、胰岛素抵抗指数(HOM ...