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dc.contributor.authorHuang, PQ
dc.contributor.author黄培强
dc.contributor.authorRuan, YP
dc.contributor.author阮源萍
dc.date.accessioned2012-10-04T01:52:20Z
dc.date.available2012-10-04T01:52:20Z
dc.date.issued1995
dc.identifier.citationCHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,1995,16(12):1914-1916zh_CN
dc.identifier.issn0251-0790
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/13670
dc.description.abstractStarting from (S)-malic acid, the stereoselective synthesis of (4S, 5R)-1, 5-dibenzyl-4-benzyloxyl-2-pyrrolidone 9 by two methods was described, The key steps in the synthesis are two asymmetric alpha-amidoalkylation. The asymmetric alpha-amidoalkylation was easily achieved either from sulfone 7 by Ley's method or from 5 via an addition-reduction proceed io provide 9 in good (4/1 for 7) to excellent (97/3 for 5) trans stereoselectivity. Compound 9 is a chiral precursor for (-)- preussin and (3S, 4R)-4-amino-3-hydroxyl-5-phenylpentanoic acid(AHPPA).zh_CN
dc.language.isozhzh_CN
dc.publisherHIGHER EDUCATION PRESSzh_CN
dc.subjectpreussinzh_CN
dc.subject4-amino-3-hydroxyl-5-phenylpentanoic acidzh_CN
dc.subjectasymmetric synthesiszh_CN
dc.subjectalpha-amidoalkylationzh_CN
dc.subject1,5-dibenzyl-4-benzyloxyl-2-pyrrolidonezh_CN
dc.titleStudies on the asymmetric synthesis of pyrrolidine alkaloids and related compounds .1. Synthesis of a chiral precursor for preussin and AHPPAzh_CN
dc.typeArticlezh_CN


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