Now showing items 1-6 of 6
Interacting with HBsAg compromises resistance of Jumping translocation breakpoint protein to ultraviolet radiation-induced apoptosis in 293FT cells
(CANCER LETT, 2009-11-28)
Jumping translocation breakpoint protein (JTB) is suppressed in many cancers, implying it plays a role in the neoplastic transformation of cells. In order to explore the role of JTB in the carcinogenesis of liver, we used ...
Notch1 signaling inhibits growth of EC109 esophageal carcinoma cells through downmodulation of HPV18 E6/E7 gene expression
(ACTA PHARMACOL SIN, 2009-02)
Aim: To investigate the role of the Notch1 signaling pathway in growth arrest of an esophageal carcinoma cell line (EC109) in vitro and the mechanism involved. Methods: An intracellular domain of Notch1 (ICN) was transfected ...
Autoimmune regulator initiates the expression of promiscuous genes in thymic epithelial cells
(IMMUNOL INVEST, 2008)
The expression of peripheral antigens in the thymus, known as promiscuous gene expression, has been implicated in T cell tolerance and autoimmunity. Here we identified thymic epithelial cells (TECs) as the main cell type ...
Effects of endogenous beta-amyloid overproduction on tau phosphorylation in cell culture
(J NEUROCHEM, 2006-08)
Alzheimer's disease is characterized by beta-amyloid (A beta) overproduction and tau hyperphosphorylation. Recent studies have shown that synthetic A beta promotes tau phosphorylation in vitro. However, whether endogenously ...
Protective effects of apocynin and allopurinol on ischemia/reperfusion-induced liver injury in mice
(WORLD J GASTROENTERO, 2008-05-14)
AIM: To determine the effects of allopurinol, an inhibitor of xanthine oxidase, and apocynin, an inhibitor of NADPH oxidase, on oxidant stress and liver injury caused by hepatic ischemia/reperfusion (I/R) procedure in mice. ...
Inhibition of P-TEFb (CDK9/Cyclin T) kinase and RNA polymerase II transcription by the coordinated actions of HEXIM1 and 7SK snRNA
The positive transcriptional elongation factor b (P-TEFb), consisting of CDK9 and cyclin T, stimulates transcription by phosphorylating RNA polymerase II. It becomes inactivated when associated with the abundant 7SK snRNA. ...