Mesoscopic-Functionalization of Silk Fibroin with Gold Nanoclusters Mediated by Keratin and Bioinspired Silk Synapse
Xiao Bing Yan
Wei Dong Yu
Xiang Yang Liu
- 材料学院－已发表论文 
【Abstract】Silk fibroin (SF) offers great opportunities in manufacturing biocompatible/partially biodegradable devices with environmental benignity and biomedical applications. To obtain active SF devices of next generation, this work is to demonstrate a new functionalization strategy of the mesoscopic functionalization for soft materials. Unlike the atomic functionalization of solid materials, the meso-functionalization is to incorporate meso-dopants, i.e., functional molecules or nanomaterials, quantum dots, into the mesoscopic networks of soft materials. In this work, wool keratin (WK) molecules were adopted as mediating molecules to incorporate gold nanoclusters (AuNCs), into the mesoscopic networks of SF. It follows from our analyses that the β-crystallites between WK and SF molecules establish the binding between WK@AuNCs and the SF networks. The incorporated WK@AuNCs are electron rich and serve as electronically charged nano particles to bridge the growth of Ag filaments in bio-degradable WK@AuNCs–SF memristors. The meso-functionalization can greatly enhance the performance of SF materials and endows them with new functionalities. This can be highlighted by biocompatible/partly degradable WK@AuNCs functionalized SF resistive random-access memories, having the enhanced resistive switching memory performance, and the unique synapse characteristics and the capability of synapse learning compared with neat SF devices, and of great importance in nonvolatile memory, analog circuits, and neuromorphic applications.
Description2017年9月，厦门大学物理科学与技术学院刘向阳教授团队与河北大学闫小兵副教授团队合作, 在Small上发表此论文，第一次将功能化蚕丝用于制造阻变存储/神经元突触电子元件。这种蚕丝基生物仿生元器件, 可制成生物相容/可植入/可降解生物电子芯片, 在人工智领域以及生物医药方面，具有重要的应用前景。The work was supported by NUS tear 1 funding (WBS: R-144-000-367-112), the 111 Project (Grant No. B16029), National Natural Science Foundation of China (Grant Nos. 21404087 and 61674050, U1405226), Fujian Provincial Department of Science & Technology (Grant Nos. 2014H6022, 2015J05109), Natural Science Foundation of Guangdong Province (Grant No. 2015A030310007), 1000 Talents Program, and President Foundation from Xiamen University (Grant No. 20720160088), Ph. D. Programs Foundation of Ministry of Education of China (Grant No. 20130121110018). One of the authors, the primary affiliation of X.Y.L. is the Department of Physics, National University of Singapore. The authors are grateful to the China Scholarship Council (CSC) for the scholarship (Grant No. 201506630067) provided to one of the authors (Xing).
CitationWiley Online Library，Small，Advanced science news,2017,1702390