Studies on the antitumor antimony(III) triaminocarboxylic complexonates. Crystal structures of NH4[Sb(Hdtpa)].H2O and Na[Sb(Hdtpa)].4(1/2) H2O (dtpa=diethylenetriaminepentaacetic acid)
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The structures of NH4[Sb(Hdtpa)]. H2O(1) and Na[Sb(Hdtpa)]. 4 1/2H(2)O(2) were determined by single-crystal X-ray studies. In both complexes, the Ligand dtpa, which is singly protonated, coordinates in a octadentate fashion involving the three nitrogen atoms and five of the carboxylate oxygen atoms of the ligand. The best description appears to be that of a psi-monocapped square antiprism with N(I) being the capping atom and a lone electron pair located on the basal plane of the coordination polyhedron. Bond valence sums were calculated and are given for all Sb(II)-dtpa chelates available to date, and preliminary tests for antitumor activity as well as structure-activity relationships: ate also presented, Crystallographic data: 1, C14H23N4O10Sb . H2O, monoclinic, P2(1)/n, a=6.867(1), b=14. 427(1), c=20.049(1) Angstrom, beta=91.89(1)degrees, Z=4. A total of 3520 reflections was used in the refinement which converged to a final R value of 0.0305; 2, C14H19N3NaO10Sb . 4 1/2 H2O, triclinic, P (1) over bar, a=7.601(1), b=8.576(1), c=17.688(4) Angstrom, a=99. 11(1), beta= 97.01(1), gamma=97.11(1)degrees, Z=2. A total of 3831 reflections was used in the refinement which converged to a final R value of 0.0487.