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dc.contributor.authorZhao, YB
dc.contributor.author赵一兵
dc.contributor.authorCi, YX
dc.contributor.authorChang, WB
dc.date.accessioned2012-08-13T04:17:00Z
dc.date.available2012-08-13T04:17:00Z
dc.date.issued1997
dc.identifier.citationSCIENCE IN CHINA SERIES B-CHEMISTRY,1997,40(4):434-441zh_CN
dc.identifier.issn1001-652X
dc.identifier.urihttp://dx.doi.org/doi:10.1007/BF02877761
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/13479
dc.description.abstractTetracycline antibiotics could be degraded after being heated in boiling-water bath in alkaline solution (in KOH medium). The fluorescence excitation and emission wavelengths of the degradation products changed and the fluorescence intensity increased by 5-190 folds as compared with that of antibiotics themselves. It was considered that there occurred a nucleophilic ring rupture reaction to form the degradation products with lactonic structure. The inter action of the lone pair electrons of oxygen on the degradation products with the conjugated pi electrons induced the increase of the delocalization for the conjugated electron system in the molecule and thus enhanced the fluorescence intensity.zh_CN
dc.language.isoenzh_CN
dc.publisherSCIENCE CHINA PRESSzh_CN
dc.subjecttetracycline antibioticszh_CN
dc.subjectalkaline degradationzh_CN
dc.subjectfluorimetryzh_CN
dc.titleFluorescence enhancing by alkaline degradation of tetracycline antibiotics and its applicationzh_CN
dc.typeArticlezh_CN


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