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dc.contributor.advisor帅建伟
dc.contributor.author赵琪
dc.date.accessioned2017-06-20T08:42:35Z
dc.date.available2017-06-20T08:42:35Z
dc.date.issued2017-01-06
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/134364
dc.description.abstractMicroRNA(miRNA)是内生的非编码RNA,通常涉及动物和植物不同的生物过程。它们与转录因子和下游基因相互作用,形成复杂并且高度关联的调控网络。为了认识一些发挥重要基础调控作用的代表性模块,我们构建了一个包含miRNA的前馈环路模型,该模型包含转录因子调控miRNA和目标基因。根据miRNA和转录因子对基因表达不同的相互作用关系,四种可能的前馈环路结构与两类gate函数被引入。当转录因子的生成率是常数时,我们发现除了Co1环路外,其它模块中的目标基因水平都表现出脉冲行为。进一步,当系统输入信号为方波刺激时,我们观察到在ANDgate条件下的In2环路中,目标基因在刺激出现时更鲁棒;当刺...
dc.description.abstractMicroRNAs (miRNA) are endogenous non-coding RNAs which participate in diverse biological processes in animals and plants. They are known to join together with transcription factors and downstream gene, forming a complex and highly interconnected regulatory network. To recognize a few overrepresented motifs which are expected to perform important elementary regulatory functions, we constructed a co...
dc.language.isozh_CN
dc.relation.urihttps://catalog.xmu.edu.cn/opac/openlink.php?strText=54679&doctype=ALL&strSearchType=callno
dc.source.urihttps://etd.xmu.edu.cn/detail.asp?serial=58575
dc.subject前馈环路
dc.subject网络模块
dc.subject动力学响应
dc.subjectmiRNA
dc.subject基因表达
dc.subjectFeed-forward loop
dc.subjectnetwork motif
dc.subjectdynamical response
dc.subjectmiRNA
dc.subjectgene expression
dc.titleMicroRNA与转录因子相互作用对基因表达影响的研究
dc.title.alternativeEffect of dynamic interaction between microRNA and transcription factor on gene expression
dc.typethesis
dc.date.replied2016-10-12
dc.description.note学位:博士后
dc.description.note院系专业:物理科学与技术学院_理论物理
dc.description.note学号:2013170047


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