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dc.contributor.authorHuang, PQ
dc.contributor.author黄培强
dc.contributor.authorZheng, XA
dc.contributor.authorWang, SL
dc.contributor.authorYe, JL
dc.contributor.authorJin, LR
dc.contributor.authorChen, Z
dc.date.accessioned2012-07-06T02:12:52Z
dc.date.available2012-07-06T02:12:52Z
dc.date.issued2000-06-12
dc.identifier.citationTETRAHEDRON-ASYMMETRY,1999,10(17):3309-3317zh_CN
dc.identifier.issn0957-4166
dc.identifier.urihttp://dx.doi.org/10.1016/S0957-4166(99)00321-3
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/13162
dc.description.abstractSuccessive treatment of a phenyl thioether derived from (S)-malic acid with n-BuLi, lithium naphthalenide (LN), and electrophiles led to 4-hydroxy-3-substituted 2-pyrrolidinones in one-pot and in high regio- and diastereoselectivity at C-3. N-Debenzylation of 1-benzyl-4-hydroxy-2-pyrrolidinone using LN afforded naturally occurring (-)-(S)-4-hydroxy-2-pyrrolidinone. (-)-(3S,4S)-4-Hydroxy-3-methyl-2-pyrrolidinone, the lactam form of the y-amino acid residue found in marine natural products, bistramides, was prepared by the same method. (C) 1999 Elsevier Science Ltd. All rights reserved.zh_CN
dc.language.isoenzh_CN
dc.publisherPERGAMON-ELSEVIER SCIENCE LTDzh_CN
dc.titleA new approach to (S)-4-hydroxy-2-pyrrolidinone and its 3-substituted analogueszh_CN
dc.typeArticlezh_CN


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