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A new approach to (S)-4-hydroxy-2-pyrrolidinone and its 3-substituted analogues

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A new approach to (S)-4-hydroxy-2-pyrrolidinone and its 3-substituted analogues.htm (413bytes)
Date
2000-06-12
Author
Huang, PQ
黄培强
Zheng, XA
Wang, SL
Ye, JL
Jin, LR
Chen, Z
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  • 化学化工-已发表论文 [14469]
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Abstract
Successive treatment of a phenyl thioether derived from (S)-malic acid with n-BuLi, lithium naphthalenide (LN), and electrophiles led to 4-hydroxy-3-substituted 2-pyrrolidinones in one-pot and in high regio- and diastereoselectivity at C-3. N-Debenzylation of 1-benzyl-4-hydroxy-2-pyrrolidinone using LN afforded naturally occurring (-)-(S)-4-hydroxy-2-pyrrolidinone. (-)-(3S,4S)-4-Hydroxy-3-methyl-2-pyrrolidinone, the lactam form of the y-amino acid residue found in marine natural products, bistramides, was prepared by the same method. (C) 1999 Elsevier Science Ltd. All rights reserved.
Citation
TETRAHEDRON-ASYMMETRY,1999,10(17):3309-3317
URI
http://dx.doi.org/10.1016/S0957-4166(99)00321-3
https://dspace.xmu.edu.cn/handle/2288/13162

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