Asymmetric synthesis of (-)-(R)-pyrrolam A starting from (S)-malic acid
- 化学化工－已发表论文 
An asymmetric synthesis of natural (-)-pyrrolam A starting from natural (S)-malic acid is described. The stereogenic center was established via a highly trans-diastereoselective reductive alkylation procedure. A tandem base-induced intramolecular amide N-substitution and tosic acid elimination led to the target molecule. (C) 1999 Elsevier Science Ltd. All rights reserved.