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dc.contributor.advisor严重玲
dc.contributor.author胡泳华
dc.date.accessioned2017-06-20T08:21:17Z
dc.date.available2017-06-20T08:21:17Z
dc.date.issued2017-03-27
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/130402
dc.description.abstract酪氨酸酶(EC1.14.18.1)是一种含铜的氧化还原酶,广泛分布于微生物、动植物及人体中,是生物体生命活动的关键酶。它具有独特的双重催化功能,可以使L-酪氨酸酶羟基化形成L-3,4-二羟基苯丙氨酸(L-DOPA),再催化L-DOPA形成多巴醌,多巴醌经过一系列的聚合反应后形成黑色素。酪氨酸酶在生物体中具有重要的生理功能,参与形成黑色素以保护皮肤和眼睛低于紫外线的辐射,参与昆虫的蜕皮及果蔬的褐变等。一旦酪氨酸酶异常表达,会引起黑色素沉积和果蔬褐变以影响其美观,因此酪氨酸酶抑制剂的研究引起了广泛的关注。 本文从化学合成、商品化合物以及抗生素三种途径中筛选酪氨酸酶抑制剂,系统地研究了合成的1,2...
dc.description.abstractTyrosinase (EC 1.14.18.1), a copper containing enzyme, is widely distributed in microorganisms, animals, plants and human beings. Tyrosinase has unique dual catlytic function, which can hydroxylate L-tyrosine into L-DOPA, catalytic L-DOPA into dopamine quinone, and then after a series of polymerization to form melanin. Tyrosinase has important physiological function in the organism, which partcipa...
dc.language.isozh_CN
dc.relation.urihttp://210.34.4.28/opac/openlink.php?strText=55817&doctype=ALL&strSearchType=callno
dc.source.urihttp://210.34.4.13:8080/lunwen/detail.asp?serial=58116
dc.subject酪氨酸酶
dc.subject抑制机理
dc.subject1,2,4-三唑衍生物
dc.subject肉桂酸衍生物
dc.subject抗生素
dc.subjecttyrosinase
dc.subjectinhibitory mechanism
dc.subject1,2,4- triazole derivaties
dc.subjectcinnamic acid derivatives
dc.subjectantibiotic
dc.title酪氨酸酶特异抑制剂的筛选及作用机理研究
dc.title.alternativeInvestigations on screening specific tyrosinase inhibitors and their inhibitory effects
dc.typethesis
dc.date.replied2016-06-18
dc.description.note学位:博士后
dc.description.note院系专业:环境与生态学院_生态学
dc.description.note学号:2014170039


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