Simultaneous on-line dissolution monitoring of multicomponent solid preparations containing vitamins B1, B2
- 化学化工－已发表论文 
A unique stopped-flow flow injection analysis system for simultaneous synchronous spectrofluorimetric on-line dissolution monitoring of multi-component solid preparations that makes use of a fiber-optic sensor was presented. A new means of in vitro therapeutic drug monitoring was developed by hyphenating the fiber-optic sensor technique and a chemometric method. An artificial neural network method was applied to construct the mathematical model for the simultaneous analysis of the mixture of vitamins B-1, B-2 and B-6 by synchronous spectrofluorimetry. The selection of the wavelength interval, the pH of the carrier solution and other experimental conditions were investigated, and discussed. The proposed method has been applied to the dissolution monitoring of vitamin B tablets with satisfactory results. The recovery was 97.8-105%, and the relative standard deviation was 1.1-7.5%, The dissolution parameters of vitamins B-1, B-2 and B-6 in the vitamin B complex tablets, which were derived from a best mathematical model using the proposed method, were furnished. The system could provide a profitable new technique for simultaneous on-line process monitoring of therapeutic drugs and their metabolites in biological body fluids. (C) 2000 Elsevier Science B.V. All rights reserved.