戊型肝炎病毒基因间交叉优势中和表位的结构基础和功能研究
Structural and Functional Insights into a Cross-genotype, Immunodominant and Neutralization Epitope of Hepatitis E Virus
Date
2017-03-23Collections
- 公共卫生－学位论文 [276]
Abstract
戊型肝炎（HepatitisE，HE）是由戊型肝炎病毒（HepatitisEvirus，HEV）引起的病毒性肝炎，近年来戊型肝炎已经成为全球卫生系统的严重负担。2012年WHO最新的一份报告中指出在全世界范围内每年约有1400万例临床戊肝患者，死亡人数达到30万，并造成5200例胎儿死亡。戊肝病例的死亡率约为0.2-4%。孕妇、老年人等免疫力低下人群和已有基础性肝病的患者感染戊肝病毒后症状尤甚，其中孕妇的死亡率可以高达到20%。 戊型肝炎病毒是一种单链、正义的RNA病毒，分属于肝炎病毒科戊肝病毒属，基因组约为7.2kb，含有三个开放阅读框（OpenReadingFrame，ORF），其中OR... Hepatitis E was caused by the hepatitis E virus infection. It is increasing the severe burden for the global public health recently. As reported by WHO, an estimated 14 million symptomatic cases of HEV infection, with 300,000 deaths and 5200 stillborn. The mortality rate ranges from 0.2% to 4% among the hepatitis E cases. However, it will cause higher mortality rate for the pregnant women, aged pe...