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dc.contributor.advisor林忠宁
dc.contributor.advisor林育纯
dc.contributor.author庄群瑛
dc.date.accessioned2017-06-20T08:09:54Z
dc.date.available2017-06-20T08:09:54Z
dc.date.issued2017-03-28
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/128529
dc.description.abstract目的:原发性肝细胞癌(hepatocellularcarcinoma,HCC)是我国公共卫生关注的热点问题之一,寻找增强HCC化疗敏感性的有效干预靶点具有重要意义。蛋白磷酸酶2A(proteinphosphatase2A,PP2A)是重要的肿瘤抑制因子;PPP2R2D基因编码的PP2A-B55δ亚基参与细胞周期有丝分裂调控。我们前期研究验证了PPP2R2D基因3’-非翻译区(3’-untranslatedregion,3’UTR)的+15G>C多态性位点受微小RNA-133b(microRNA-133b,miR-133b)靶向调控,本研究旨在探讨miR-133b调控PP2A-B55δ影响HCC...
dc.description.abstractObjective: Hepatocellular carcinoma (HCC) remains a major public health problem in China. The identification of effective targets for enhancing HCC chemosensitivity is of great significance. Protein phosphatase 2A (PP2A) is an important tumor suppressor. PP2A-B55δ subunit, encoded by the PPP2R2D gene, play a critical role in the regulation of cell cycle and mitosis. Our previous studies revealed t...
dc.language.isozh_CN
dc.relation.urihttps://catalog.xmu.edu.cn/opac/openlink.php?strText=55871&doctype=ALL&strSearchType=callno
dc.source.urihttps://etd.xmu.edu.cn/detail.asp?serial=56219
dc.subject蛋白磷酸酶2A-B55δ亚基
dc.subject肝细胞癌
dc.subject化疗敏感性
dc.subjectmiR-133b
dc.subject单核苷酸多态性
dc.subjectprotein phosphatase 2A-B55δ subunit
dc.subjecthepatocellular carcinoma
dc.subjectchemotherapy sensitivity
dc.subjectmiR-133b
dc.subjectsingle nucleotide polymorphisms
dc.titlemiR-133b调控蛋白磷酸酶2A-B55δ亚基影响肝细胞癌化疗敏感性的机制研究
dc.title.alternativeProtein phosphatase 2A-B55δ enhances chemotherapy sensitivity of human hepatocellular carcinoma under the regulation of microRNA-133b
dc.typethesis
dc.date.replied2016-05-24
dc.description.note学位:医学硕士
dc.description.note院系专业:公共卫生学院_卫生毒理学
dc.description.note学号:32720131150568


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