Extraction of insecticidal toosendanin from meliaceae by supercritical CO_2
- 化学化工－已发表论文 
[中文文摘]苦楝素是楝科植物中制备植物源农药的主要杀虫成分。针对不同种源楝树的皮、叶及果实,采用溶剂浸提法提取筛选苦楝素含量较高的种源作为实验原料,采用乙醇提取,考察液固质量比、提取时间和提取次数等参数对苦楝素提取率的影响。当液固质量比为25∶1、提取时间为4 h、提取次数为3次时,苦楝素的提取率达18%。进一步采用超临界CO2萃取考察压力、温度、萃取时间、原料粒径和夹带剂等参数对苦楝素萃取率的影响,当温度为40℃、压力为20 MPa、时间为2.0 h、原料粒径为40目、夹带剂乙醇质量为CO2质量的12.5%时,苦楝素的萃取率达43.5%。在对萃取液结晶纯化中成功分离得到质量分数达98%的苦楝素。[英文文摘]Toosendanin is the main insecticidal component of meliaceae plants for producing botanical insecticides.The extraction of toosendanin from the parks,leaves and fruits of the various meliaceae plants was studied by using ethanol,and the part of the meliaceae plants with the maximal mass fraction of toosendanin was selected as experimental materials.The effects of the mass ratio of liquid to solid,extraction time,and extraction times on the yield of toosendan were investigated by using ethanol extraction method. The yield of toosendanin is up to 18% at them ass ratio of liquid to so lid of 25:1, extraction time of 4h and extract ing 3 times. The effects of pressure, temperature, extraction time, and the partic le size of materials and the dosage of mod if iers on the yield of toosendanin w ere investigated bym eans of supercritical CO2 extraction. The yield of toosendan in is up to 43.5% when ethanol is used as mod ifier with its mass 12.5% of CO2 mass at temperature 40,pressure 20 MPa,extraction time 2h and material particle size 40 mesh. The toosendanin crystal with mass fraction 98% was separated from the extracts by using crystalliza tionm ethod.