Polydopamine-Coated Manganese Carbonate Nanoparticles for Amplified Magnetic Resonance Imaging-Guided Photothermal Therapy
- 化学化工－已发表论文 
【Abstract】This study reports a multifunctional nanoparticle (NP) with function of amplified magnetic resonance image (MRI)-guided photothermal therapy (PTT) by the surface coating of polydopamine (PDA) shell. Importantly, by means of introducing the surface coating of PDA，it helps entrap large quantities of water around NPs and allow more efficient water exchange， leading to greatly improved MR contrast signals compared with the one without PDA coating. Besides，the distinct photothermal effect can be obtained arising from the strong absorption of PDA in the near-infrared (NIR) region. By synthesizing the multifunctional MnCOs@PDA NPs as example，we found that the longitudinal relaxivity (ri) of MnCOs NPs might improve from 5.7 to 8.3 mM-is-i. Subsequently，In vitro MRI and PTT results verified that MnCOs@PDA could serve well as an excellent MRI/PTT theranostic agent. Furthermore， the MnCO3@PDA nanoparticles were applied as MRI/PTT theranostic agent for in vivo MRI-guided photothermal ablation of tumors by intratumorally injection in 4T1 tumor bearing-mice. The MR imaging result shows a significantly bright MR image in the tumor site. The MnCO3@PDA-mediated PTT result shows high therapy efficiency as a result of their high photothermal conversion efficiency. The present strategy of amplified MRI-guided PTT based on PDA coating on NPs will be widely applicable to other multifunctional nanoparticles.