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dc.contributor.authorZhang, ZL
dc.contributor.authorPang, DW
dc.contributor.authorZhang, RY
dc.contributor.authorYan, JW
dc.contributor.author颜佳伟
dc.contributor.authorMao, BW
dc.contributor.author毛秉伟
dc.contributor.authorQi, YP
dc.date.accessioned2012-05-22T00:56:55Z
dc.date.available2012-05-22T00:56:55Z
dc.date.issued2001-12-13
dc.identifier.citationBioconjugate Chem., 2002, 13 (1):104–109zh_CN
dc.identifier.issn1043-1802
dc.identifier.urihttp://dx.doi.org/doi: 10.1021/bc0155263
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/12481
dc.description.abstractThe immobilization of thiol-derivatized DNA on a Au (111) single crystal surface by self-assembly has been investigated by electrochemical scanning tunneling microscopy (EC-STM). Continuous potential-dependent orientation changes of double-stranded oligodeoxynucleotides (ODN) have been observed in a certain potential range from 200 to 600 mV (versus SCE). It is suggested that the DNA duplexes stand straight on the gold surface at potentials negative of the potential of zero charge (pzc) and then lay down on the surface when the potential shifts positively. These results are in agreement with the expectation based on the Coulombic interaction consideration between negatively charged DNA helices and gold surface. As the applied potential shifts positively, the surface charge changes from negative to positive, that is, the Coulombic force between negatively charged DNA helices and gold surfaces changes from repulsion to attraction. However, for the single-stranded oligodeoxynucleotides, no distinct changes in the surface structure were observed with the applied potential.zh_CN
dc.language.isoenzh_CN
dc.publisherAMER CHEMICAL SOCzh_CN
dc.titleInvestigation of DNA orientation on gold by EC-STMzh_CN
dc.typeArticlezh_CN


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