Penta-coordinate phosphorous compounds and biochemistry
Date
2002Author
Lin, CX
林长学
Li, YM
李艳梅
Cheng, CM
成昌梅
Han, B
韩波
Wan, R
万荣
Feng, YB
冯亚兵
Zhao, YF
赵玉芬
Collections
- 化学化工-已发表论文 [14469]
Abstract
The relationship between penta-coordinate phosphorus compounds and biochemistry is briefly reviewed. Some interesting phenomena such as peptide formation, ester formation, ester exchange on phosphorus and N to O migration occur at room temperature when the amino group of amino acid is associated with phosphoryl group. Serine or threonine in conjugate of nucleoside-amino acid could recognize different nucleobases. N-phosphoryl Histine and Ser-His dipeptide could cleavage nucleic acid, protein and ester in neutral medium. It is found that the above phenomena all undergo penta-coordinate intermediate of phosphorus atom, which is proposed as the key factor to determine their activities.