Synthesis and bioactivity of 5-avermectin B-1a esters

Abstract

Ten 5-Avermectin B-1a ester derivatives were prepared from avermectin B-1a and carboxylic acids in the systems of DCC/DMAP. Their chemical structures were confirmed by IR, H-1 NMR, C-13 NMR and MS. Their insecticidal, activity was evaluated against Aphis gossypii. Glover and Tetranychus truncatus E-hara. It was found that some compounds showed a higher insecticidal activity than Avermectin.