A versatile approach for the asymmetric synthesis of 3-alkyl-isoindolin-1-ones
- 化学化工－已发表论文 
A flexible approach to (R)-3-alkyl-isoindolin-1-ones and (R)3-aryl-isoindolin-1-ones via a diastereoselective reductive-alkylation is described. Present method is versatile in scope, allowing the easy introduction of various C-3 substituents by Grignard addition to phthalimide derived from (R)-phenylglycinol. 3-Alkyl-3-hydroxy-isoindolin-1-ones can also be obtained in the first step of the present method.