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dc.contributor.authorPan, ED
dc.contributor.author潘恩德
dc.contributor.authorLi, YY
dc.contributor.author李岩云
dc.contributor.authorDong, ZR
dc.contributor.author董振荣
dc.contributor.authorChen, JS
dc.contributor.author陈建珊
dc.contributor.authorLi, BZ
dc.contributor.author李宝珠
dc.contributor.authorZhang, H
dc.contributor.author章慧
dc.contributor.authorGao, JX
dc.contributor.author高景星
dc.date.accessioned2012-04-13T00:56:23Z
dc.date.available2012-04-13T00:56:23Z
dc.date.issued2003
dc.identifier.citationCHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,2003,24(9):1615-1617zh_CN
dc.identifier.issn0251-0790
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/12059
dc.description.abstractEnantioselective reduction of prochiral ketones with 2-propanol or formic acid catalyzed by chiral metal complexes has been developed as a synthetic method complementary to asymmetric hydrogenation in the past decade. However, these processes are necessary to be improved for practical use in organic synthesis because of low catalytic activity and insufficient enantioselectivity. In this paper, we wish to report an excellent catalytic system generated in situ from iridium complex IrCl (Ph3P)(3) and chiral tetradentate diaminodiphosphine ligand for asymmetric transfer hydrogenation of various aromatic ketones. For isobutyrophenone transfer hydrogenation, the corresponding optically active alcohol was obtained in 93% yield and with up to 99 % e. e. after 5 h at 28 degreesC. Propiophenone was a better substrate with respect to catalytic activity and enantioselectivity in the presence of base as a co-catalyst. The conversion of propiophenone reached 95. 8 % and the turnover number as high as 3 193 h(-1). These results will provide a useful index for further designing practical chiral catalytic systems.zh_CN
dc.language.isozhzh_CN
dc.publisherHIGHER EDUCATION PRESSzh_CN
dc.subjectchiral aminophosphine ligandzh_CN
dc.subjectiridium complexzh_CN
dc.subjectaromatic ketoneszh_CN
dc.subjectenantioselective transfer hydrogenationzh_CN
dc.titleHighly enantioselective transfer hydrogenation of aromatic ketoneszh_CN
dc.typeArticlezh_CN


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