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Highly enantioselective transfer hydrogenation of aromatic ketones

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芳香酮的高效对映选择性转移氢化.pdf (2.219Mb)
Date
2003
Author
Pan, ED
潘恩德
Li, YY
李岩云
Dong, ZR
董振荣
Chen, JS
陈建珊
Li, BZ
李宝珠
Zhang, H
章慧
Gao, JX
高景星
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  • 化学化工-已发表论文 [14469]
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Abstract
Enantioselective reduction of prochiral ketones with 2-propanol or formic acid catalyzed by chiral metal complexes has been developed as a synthetic method complementary to asymmetric hydrogenation in the past decade. However, these processes are necessary to be improved for practical use in organic synthesis because of low catalytic activity and insufficient enantioselectivity. In this paper, we wish to report an excellent catalytic system generated in situ from iridium complex IrCl (Ph3P)(3) and chiral tetradentate diaminodiphosphine ligand for asymmetric transfer hydrogenation of various aromatic ketones. For isobutyrophenone transfer hydrogenation, the corresponding optically active alcohol was obtained in 93% yield and with up to 99 % e. e. after 5 h at 28 degreesC. Propiophenone was a better substrate with respect to catalytic activity and enantioselectivity in the presence of base as a co-catalyst. The conversion of propiophenone reached 95. 8 % and the turnover number as high as 3 193 h(-1). These results will provide a useful index for further designing practical chiral catalytic systems.
Citation
CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,2003,24(9):1615-1617
URI
https://dspace.xmu.edu.cn/handle/2288/12059

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