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dc.contributor.authorZhang, Jiliang
dc.contributor.authorZuo, Zhenghong
dc.contributor.author左正宏
dc.contributor.authorWang, Yuqing
dc.contributor.authorYu, Ang
dc.contributor.authorChen, Yixin
dc.contributor.author陈亦欣
dc.contributor.authorWang, chonggang
dc.contributor.author王重刚
dc.date.accessioned2012-04-12T06:38:29Z
dc.date.available2012-04-12T06:38:29Z
dc.date.issued2010-10-20
dc.identifier.citationChemosphere Volume 82, Issue 3, January 2011, Pages 437–442zh_CN
dc.identifier.issn0045-6535
dc.identifier.urihttp://dx.doi.org/doi:10.1016/j.chemosphere.2010.09.057
dc.identifier.uriWOS:000286493800019
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/12055
dc.description.abstractTributyltin (TBT) is a ubiquitous marine environmental contaminant characterized primarily by its reproductive toxicity. However, the embryotoxicity of TBT has not been extensively described, especially in fishes. The aim of this study was to investigate the developmental toxicity of waterborne TBT at environmental levels (0, 0.1, 1, and long L(-1) as Sn) on Sebastiscus marmoratus embryos. Our study showed that TBT reduced the hatchability and caused apparent morphological abnormalities including dorsal curvature, severely twisted tails and pericardial edema. In addition, localized apoptosis was found in the tail regions of embryos after TBT exposure. The study provided a possible mechanistic link between apoptosis and TBT-induced twisted tails abnormality. TBT exposure induced retinoid X receptor cc expression in S. marmoratus embryos at the 0.1 and 1 ng L(-1) group, which would be responsible for the increasing apoptotic cells induced by TBT. The results of the present study have widespread implications for environmental ecological assessment, management and the etiology of developmental defects. (C) 2010 Elsevier Ltd. All rights reserved.zh_CN
dc.description.sponsorshipNational Natural Science Foundation of China[20977071]; Natural Scientific Fund in Fujian Province, China[2009J01225]zh_CN
dc.language.isoenzh_CN
dc.publisherPERGAMON-ELSEVIER SCIENCE LTDzh_CN
dc.subjectTributyltin; Embryozh_CN
dc.subjectDevelopmentzh_CN
dc.subjectApoptosiszh_CN
dc.subjectRetinoid X receptorzh_CN
dc.subjectSebastiscus marmoratuszh_CN
dc.titleTributyltin chloride results in dorsal curvature in embryo development of Sebastiscus marmoratus via apoptosis pathwayzh_CN
dc.typeArticlezh_CN


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