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ESI-MS studies on novel liquid homo-peptide libraries and their conjugate libraries directed by phosphorus oxychloride

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ESI-MS studies on novel liquid homo-peptide libraries and their conjugate libraries directed by phosphorus oxychloride.htm (400bytes)
Date
2003
Author
Zhou, N
Hu, LM
Zhou, GJ
Liu, Y
Lu, K
Zhao, YF
赵玉芬
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  • 化学化工-已发表论文 [14469]
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Abstract
The reactions of natural non-polar amino acids with phosphorus oxychloride were investigated. Some non-polar amino acids, such as L-Phe, L-Leu and L-Val were treated with phosphorus oxychloride, then quenched with water or some bioactive compounds (L-menthol, cinchonidine and benzylamine), and yielded the corresponding peptide and peptide conjugate libraries. ESI-MS/MS was used to study the products of the reaction and confirm the structure of the library. This paper reports a simple method to synthesize the homo-oligo-peptide libraries and peptide conjugated libraries.
Citation
LETTERS IN PEPTIDE SCIENCE,2003,10(1):11-14
URI
http://dx.doi.org/doi:10.1007/BF02443637
https://dspace.xmu.edu.cn/handle/2288/12011

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