Karyopherins in nuclear transport of homeodomain proteins during development
Tartakoff, Alan M.
- 生命科学－已发表论文 
Homeodomain proteins are crucial transcription factors for cell differentiation, cell proliferation and organ development. Interestingly, their homeodomain signature structure is important for both their DNA-binding and their nucleocytoplasmic trafficking. The accurate nucleocytoplasmic distribution of these proteins is essential for their functions. We summarize information on (a) the roles of karyopherins for import and export of homeoproteins, (b) the regulation of their nuclear transport during development, and (c) the corresponding complexity of homeoprotein nucleocytoplasmic transport signals. This article is part of a Special Issue entitled: Regulation of Signaling and Cellular Fate through Modulation of Nuclear Protein Import. (C) 2011 Elsevier B.V. All rights reserved.
出处Biochimica et Biophysica Acta (BBA) - Molecular Cell Research Volume 1813, Issue 9, September 2011, Pages 1654–1662