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dc.contributor.authorCao, Shuo-Hui
dc.contributor.authorXie, Tang-Tang
dc.contributor.authorCai, Wei-Peng
dc.contributor.authorLiu, Qian
dc.contributor.authorLi, Yao-Qun
dc.contributor.author李耀群
dc.date.accessioned2012-03-16T01:44:54Z
dc.date.available2012-03-16T01:44:54Z
dc.date.issued2011-01-25
dc.identifier.citationJ. Am. Chem. Soc., 2011, 133 (6): 1787–1789zh_CN
dc.identifier.issn0002-7863
dc.identifier.urihttp://dx.doi.org/doi:10.1021/ja107964s
dc.identifier.uriWOS:000287831800049
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/11773
dc.description.abstractWe have demonstrated the proof-of-principle of electric field assisted surface plasmon-coupled directional emission (E-SPCDE). The combination of SPCDE and electric field control produced a significant synergistic effect to amplify the right signal and suppress the wrong signal intelligently in an active strategy. A novel hairpin structured DNA biosensor based on the quenching and enhancing of fluorescence in SPCDE has been designed. With modulation of the fluorescence coupling efficiency, a high discrimination ratio up to more than 20-fold has been achieved by enhancing the signal of match and suppressing that of mismatch. E-SPCDE has shown a successful application in DNA sensing, eliminating false positives and false negatives in the detection. E-SPCDE should provide an opportunity to create a new generation of miniaturized high-performance sensing platforms especially in chip-based microarrays and to make the manipulation of the nanometer-scale processes more accessible and detectable.zh_CN
dc.description.sponsorshipNSFC[20975084, 20575055]; 973 Program of China[2007CB935600]zh_CN
dc.language.isoenzh_CN
dc.publisherAMER CHEMICAL SOCzh_CN
dc.titleElectric Field Assisted Surface Plasmon-Coupled Directional Emission: An Active Strategy on Enhancing Sensitivity for DNA Sensing and Efficient Discrimination of Single Base Mutationzh_CN
dc.typeArticlezh_CN


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